Introduction: Radiation effects observed in cells that are not irradiated are known as non-targeted effects.  Radiation induced bystander effect (RIBE) as a kind of non-targeted effect has been introduced in recent  years.  RIBE  occurs  in  unexposed  cells  which  are  related  to  adjacent  or  distant  irradiated  cells.  RIBE  contradict with "target theory" which necessitates radiation tr...

Introduction: Ionizing radiation is non-surgical treatment of brain tumors and metastases. Preclinical studies have showed main insights into harmful effects of radiation on the nervous system in vivo and in vitro. Cognitive impairment such as progressive memory, executive and attention performance deficits indicates a significant risk for patients experiencing conventional rad...

The aim of this study was to investigate the radioprotective effect of thymol as a natural product against salivary glands dysfunction induced by ionizing radiation in rats. The rats were treated with thymol at dose of 50 mg/Kg before exposure to radiation at dose 15Gy. Salivary gland function was evaluated with radioisotope scintigraphy and then salivary gland to background counts ratio was ca...

The management of locally advanced or recurrent extremity sarcoma often necessitates multimodal therapy to preserve a limb, of which isolated limb perfusion (ILP) is a key component. However, with standard chemotherapeutic agents used in ILP, the duration of response is limited. Novel agents or treatment combinations are urgently needed to improve outcomes. Previous work in an animal model has ...

Reactive oxygen species (ROS) have been indicated in the development of diseases such as cancer, cardiovascular diseases, degenerative diseases and ageing. An increasing body of evidence indicates an association between increased and persistent oxidative stress and the development of radiation damage in tissues such as skin, central nervous system and kidney. On the basis of the new hypothesis ...

The aim of this study was to investigate the radioprotective effect of thymol as a natural product against salivary glands dysfunction induced by ionizing radiation in rats. The rats were treated with thymol at dose of 50 mg/Kg before exposure to radiation at dose 15Gy. Salivary gland function was evaluated with radioisotope scintigraphy and then salivary gland to background counts ratio was ca...

Reactive oxygen species (ROS) have been indicated in the development of diseases such as cancer, cardiovascular diseases, degenerative diseases and ageing. An increasing body of evidence indicates an association between increased and persistent oxidative stress and the development of radiation damage in tissues such as skin, central nervous system and kidney. On the basis of the new hypothesis ...

primary cardiac sarcomas are very rare and there is no consensus on management. clinical presentation is usually late. despite newer diagnostic technology, prognosis remains dismal. we report a case of right atrial sarcoma in a 28-year-old man who presented with acute cardiac tamponade. emergency subxiphoid pericardial drainage stabilized the patient's critical condition. the lesion was advance...

INTRODUCTION The SCAN sarcoma workgroup aimed to develop Singapore Cancer Network (SCAN) clinical practice guidelines for the initial evaluation, diagnosis, and management of extremity soft tissue sarcoma and osteosarcoma. MATERIALS AND METHODS The workgroup utilised a consensus approach to create high quality evidence-based clinical practice guidelines suited for our local setting. RESULTS...