hodgkin lymphoma (hl) accounts for about 10% of all childhood cancers. five-year survival rates with modern therapies are now approaching >90-95% as a consequence of its significant sensitivity to both chemotherapy and radiation. the current challenge is to determine how much therapy is needed to improve survival and how to adapt treatment to the patient to prevent these long term toxicities. t...

in this review, we discuss the use of a variety of 3-d models (particularly 3-d skin, lung, breast and endothelial) in radiobiological research and highlight the differences in responses compared to 2-d culturing conditions (monolayers). we review the characteristics of existing 3-d models and aim to point out the substantial advantages 3-d cultures provide for modern radiobiology. in particula...

Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, United Kingdom; Structural Biology Group, European Synchrotron Radiation Facility, 6 rue Jules Horowitz, F-38043 Grenoble, France; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588; Centre for Chemical Biology, Department of Chemistry, University of Sheffield, Sheffield S3 7HF...

Over the last 7 years, we have focused our experimental and computational research efforts on improving our understanding of the biochemical, molecular, and cellular processing of iododeoxyuridine (IUdR) and ionizing radiation (IR) induced DNA base damage by DNA mismatch repair (MMR). These coordinated research efforts, sponsored by the National Cancer Institute Integrative Cancer Biology Progr...

The interaction of radiation with cells and tissues has a random nature. Therefore, understanding the random nature of cell killing that is determined by Poisson distribution statistics is an essential point in education of radiation biology. RadBioStat is a newly developed educational MATLAB-based software designed for computer-assisted learning of the target theory in radiation biology. Altho...

Margaret M. Tarpey, David A. Wink, and Matthew B. Grisham Department of Anesthesiology and the Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294; Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland 20814; and Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana ...