Accepted 20 March 1997 During a survey for diabetes mellitus in rural India, a 34-year-old man with polydactyly and partial blindness drew the attention of this author. He was born of a consanguineous marriage and had healthy siblings. His parents report that the milestones of developments were apparently normal up to the age of four years when they noticed his difficulty in identifying objects...

Maternal diabetes has an established aetiological link with developmental abnormalities, and the prevalence of major congenital malformations in the offspring of affected women is approximately 4-8%, compared to the general population risk of about 3%. Hallucal polydactyly, particularly with an unusual proximal placement of the extra digit, has been reported as a distinctive anomaly in diabetic...

We have carried out the study on the heart anomalies of the DHS mice and Pdn mice fetuses and newborns which are known to produce genetically induced polydactyly. The results have revealed that the heart anomalies are m,ainly isolated hypoplasia of the pulmonary artery and that these anomalies are not always associated with polydactyly. The isolated hypoplasia of the pulmonary artery show a ten...

Two cases of aplasia cutis congenita are reported here. One of the cases also had pre- and postaxial polydactyly and other digital anomalies.

Short rib–polydactyly syndrome (SRPS) type II is a rare lethal form of skeletal dysplasia, characterized by polydactyly, short limbs, short and horizontal ribs, a small ovoid tibia and major organ anomalies [1]. Prenatal diagnosis by genetic testing is not available; ultrasound plays an important role. With no prior history usually these cases are detected late in pregnancy; postnatal examinati...