BACKGROUND There is an ongoing debate as to whether early diabetic nephropathy in Type 2 diabetes mellitus may be attributed to the glomerulus or to the proximal tubule. Urinary excretion of nephrin and vascular endothelial growth factor may increase even in the normoalbuminuria stage. In the course of diabetic nephropathy, the proximal tubule may be involved in the uptake of urinary nephrin an...

The R2 dimer of mouse ribonucleotide reductase contains a dinuclear iron-oxygen cluster and tyrosyl radical/subunit. The dinuclear diferrous form reacts with dioxygen to generate the tyrosyl radical essential for the catalytic reaction that occurs at the R1 dimer. It is important to understand how the reactivity toward oxygen is related to the crystal structure of the dinuclear cluster. For the...

We prove global well-posedness for the cubic, defocusing, nonlinear Schrödinger equation on R2 with data u0 ∈ H s(R2), s > 1/4. We accomplish this by improving the almost Morawetz estimates in [9].

We consider the generalized elastica functional defined on L1(R2) as F(u) =  ∫ R2 |∇u|(α +β |div ∇u |∇u| |p)dx, if u ∈ C2(R2), +∞ else, where p > 1, α > 0, β ≥ 0. We study the L1-lower semicontinuous envelope F of F and we prove that, for any u ∈ BV(R2), F(u) can be represented by a coarea-type formula involving suitable collections of W2,p curves that cover the essential boundaries of the le...

In R2, we consider an analytic family of operators Hz , z ∈ C, whose convolution kernel is obtained by taking −z − 1 derivatives of arclength measure on the parabola (t, t2) in a homogeneous way, defined in such a way so that H−1 be the standard parabolic Hilbert transform. For a fixed z, we study the set of p for which Hz is bounded on Lp(R2) and for the critical z that captures the degree of ...

(1) Let F , F1, F2 be finite sequences of elements of R and given r1, r2. If F1 = 〈r1〉 F or F1 = F a 〈r1〉 and if F2 = 〈r2〉 F or F2 = F a 〈r2〉, then ∑(F1−F2) = r1− r2. (2) Let F1, F2 be finite sequences of elements of R. If lenF1 = lenF2, then len(F1 +F2) = lenF1 and len(F1−F2) = lenF1 and ∑(F1 +F2) = ∑F1 +∑F2 and ∑(F1−F2) = ∑F1−∑F2. (3) Let F1, F2 be finite sequences of elements of R. If lenF1 ...

where sxβ is the sample variance of x T 1 β, . . . ,x T nβ, representing variance explained by the model, and R2 is the specified value (0.1 or 0.5). The left side of (A2) is similar to what Tibshirani and Knight (1999) called the “theoretical R2,” and has the interpretation that for responses generated according to (A1), (A2), the coefficient of determination for the true model is approximatel...

The multiple correlation coefficient is used in a large variety of statistical tests and regression problems. In this article, we derive the null distribution of the square of the sample multiple correlation coefficient, R2, when a sample is drawn from a mixture of two multivariate Gaussian populations. The moments of 1−R2 and inverse Mellin transform have been used to derive the density of R2.

The purpose of the current study was to evaluate the effect of 12/15-lipoxygenase (12/15-LOX) metabolites on retinal endothelial cell (REC) barrier function. FITC-dextran flux across the REC monolayers and electrical cell-substrate impedance sensing (ECIS) were used to evaluate the effect of 12- and 15-hydroxyeicosatetreanoic acids (HETE) on REC permeability and transcellular electrical resista...

Mutations of the nucleophosmin-1 (NPM1) gene in cytogenetically normal (CN) acute myeloid leukemia (AML) identify a group of patients with more favorable prognosis. NPM1 encodes three main alternatively spliced isoforms R1(B23.1), R2(B23.2), and R3(B23.3). The expression of splice variants R1, R2 and R3 were higher in AML patients compared to normal cells of healthy volunteers (HVs), although R...