We investigated a useful chemical index for an excessive nicotinamide intake and how this excessive nicotinamide intake affects the tryptophan-nicotinamide metabolism in rats. Weaning rats were fed on a tryptophan-limited and nicotinic acid-free diet containing no, 0.003%, 0.1%, 0.2%, or 0.3% nicotinamide for 21 days. Urine samples were collected on the last day and analyzed the intermediates a...

ID: 19899 Title: Contrast-Enhanced Spectral Mammography Physical Aspects and QA

Interactive question answering (QA) systems, where a dialogue interface enables followup and clarification questions, are a recent field of research. We report our experience on the design, implementation and evaluation of a chatbot-based dialogue interface for our open-domain QA system, showing that chatbots can be effective in supporting interactive QA.

BACKGROUND Autism spectrum disorder (ASD) is still diagnosed through behavioral observation, due to a lack of laboratory biomarkers, which could greatly aid clinicians in providing earlier and more reliable diagnoses. Metabolomics on human biofluids provides a sensitive tool to identify metabolite profiles potentially usable as biomarkers for ASD. Initial metabolomic studies, analyzing urines a...

We proposed [11C]KF18446 as a selective radioligand for mapping the adenosine A2A receptors being highly enriched in the striatum by positron emission tomography (PET). In the present study, we investigated whether [11C]KF18446 PET can detect the change in the striatal adenosine A2A receptors in the rat after unilateral injection of an excitotoxin quinolinic acid into the striatum, a Huntington...

Scientific Abstract Pancreatic cancer patients frequently present with a history of depression; often newonset depressive symptoms precede the diagnosis of cancer. These patterns of psychiatric symptoms, arising prior to cancer diagnosis, suggest that the pathophysiology of depression in pancreatic cancer may result from biological changes, such as alterations in cytokine levels, that are induc...

Symptoms in the early stages of Huntington's disease (HD) are assumed to reflect basal ganglia circuit dysfunction secondary to degeneration of striatal projections to the external segment of the globus pallidus (GPe). The hypothesis that GPe lesion would ameliorate HD symptoms by "normalizing" the circuit's functioning was tested in a rat model of this disease. The performance of rats sustaini...