Abstract In response to the malaria parasite’s resistance towards quinoline-based antimalarial drugs, we have employed quinoline-containing compounds in combination with dihydropyrimidinone (DHPM) analogues as reversal agents (RAs) and investigated their activities based on DHPM’s abilities. The present study click chemistry link DHPM quinoline which offered several synthetic advantages over pr...

The title compound, C(10)H(11)N(4) (+)·Cl(-), has been synthesized by the reaction of 8-amino-quinoline and cyanamide. The dihedral angle between the plane of the guanidine group and the quinoline ring system is 68.64 (13)°. The crystal structure is stabilized by inter-molecular N-H⋯Cl hydrogen bonds.

Susceptibility to quinoline antimalarial intoxication may reflect individual genetic and drug-induced variation in neuropharmacokinetics. In this report, we describe a case of chloroquine intoxication that appeared to be prolonged by subsequent use of multiple psychotropic medications. This case highlights important new considerations for the management of quinoline antimalarial intoxication.

FeCl3- and FeBr3-mediated tandem carboarylation/cyclization of propargylanilines with diethyl benzaldehyde acetals furnished the tetracyclic core of indeno[2,1-c]quinolines. 5-Tosyl-6,7-dihydro-5H-indeno[2,1-c]quinoline and 7H-indeno[2,1-c]quinoline derivatives were obtained in good to excellent yields, respectively, by tuning the FeX3 loadings and/or reaction temperatures.

The title compound, C(13)H(11)N(3)O, a potential chemotherapeutic agent, contains a essential planar [maximum deviation = 0.0144 (14) Å] quinoline moiety. The quinoline ring system and the five-membered heterocycle form a dihedral angle of 7.81 (6)°. In the crystal, inter-molecular non-classical C-H⋯N hydrogen bonding is present.

papaver pseudo-orientale population tarom was shown to contain two major alkaloids, isothebaine (0.65%), orientalidine (0.15%) and four minor alkaloids, bracteoline, mecambridine, or and a novel alkaloid, nor-methyl or .

dna intercalators belong to aromatic heterocyclic compounds interacting reversibly with dna. these compounds have been used extremely as cytotoxic agents against cancer. in this study, the synthesis and biological activity of some novel derivatives of cyclopenta [b] quinoline-1, 8-dione as new intercalating agent were investigated. twenty novel derivatives of cyclopenta [b] quinoline-1, 8-dione...

(Thiazolyl-2-yl)hydrazones (THs) are a group of organic compounds containing both hydrazone and 1,3-thiazole pharmacophores present in many approved drugs. They have been investigated greatly recent years due to potent anticancer, antibacterial, antifungal, antituberculosis, anti-inflammatory, antiparasitic activities. In this study, one pyridine-based two quinoline-based, novel THs were synthe...

WITTERS, WELDON L. Extraction and identification of clavine and lysergic acid alkaloids from morning glories. Ohio J. Sci. 75(4): 198, 1975. Seeds from three varieties of Ipomoea grown in Ohio were examined for clavine and lysergic acid alkaloids. Three systems of extraction of ergoline alkaloids were compared with the ammonium hydroxide-methanol-chloroform method proving superior to the others...

This paper presents the alkaloids found in green, brown and red marine algae. Algal chemistry has interested many researchers in order to develop new drugs, as algae include compounds with functional groups which are characteristic from this particular source. Among these compounds, alkaloids present special interest because of their pharmacological activities. Alkaloid chemistry has been widel...