Amphipatic compounds exhibit an antimicrobial action both on bacteria and fungi. It is caused by a penetrative property of hydrophobic carbon chain of the compuound into a plasma membrane as well as by additional interaction of membrane elements and a hydrophilic amphipathic compound head. Bactericidal and fungicidal activity of this compound strongly depends on chemical environmental factors. ...

Quaternary ammonium and phosphonium salts have been screened for their toxic effect on HeLa and K562 cancer cell lines, as well as on normal HUVEC cells. Tri-n-butyl-n-hexadecylphosphonium bromide, the first phosphonium salt with a halogen anion tested against HeLa cells, was 12 times more potent (IC50 <5 μm after 24 and 48 h) than the clinically used reference compound cisplatin and 17 times m...

background: quaternary ammonium compounds (qac), which contain benzalkonium chloride as the most widely used agent, are employed as wound and skin antiseptics, as well as disinfectants in hospitals. the resistance mechanism to disinfectants is usually determine by genes which are related to resistance to quaternary ammonium compounds, namely, qace, qacδe1, qacδe1 that are found in gram-negative...

DNA-templated organic synthesis (DTS) enables new modes of controlling chemical reactivity and allows evolutionary principles to be applied to the discovery of synthetic small molecules, synthetic polymers, and new chemical reactions. The structures that can be accessed in a DNA-templated format thus far have been limited to those that can be generated in aqueous solvents. Here we report effici...

benzalkonium chloride is a quaternary ammounium compounds derivative under different names such as afxhang, hamoon, mahan etc, which have great and expanded use in sanitation and medical affairs. bactericidal activity of these disinfectants was fulfilled according to national standard method no.2842 on staph. aureus, sal. typhimouium and e. coli. this laboratory test showed that, except mahan t...

The Cover Feature shows a schematic representation of Zn plating from an aqueous electrolyte in the presence Quaternary Ammonium Salts (QASs) (upper part) and additive-free solution (bottom element). study provides insight into cycling behavior zinc anodes battery context, using QASs as additives mildly acidic electrolytes. cover was designed by one paper authors: Elisa Emanuele. More informati...