Behavioral differences between inbred strains of mice and rats have a genetic basis that can now be dissected using quantitative trait locus (QTL) analysis. Over the last 10 years, a large number of genetic loci that influence behavior have been mapped. In this article I review what that information has revealed about the genetic architecture of behavior. I show that most behaviors are influenc...

We describe a method to simultaneously detect and fine map quantitative trait loci (QTL) that is especially suited to the mapping of modifier loci in mouse mutant models. The method exploits the high level of historical recombination present in a heterogeneous stock (HS), an outbred population of mice derived from known founder strains. The experimental design is an F(2) cross between the HS an...

In addition to its potential contribution to improving animal welfare, the study of the genetics of cattle behavior may provide more general insights into the genetic control of such complex traits. We carried out a genome scan in a Holstein x Charolais cross cattle population to identify quantitative trait loci (QTL) influencing temperament-related traits. Individuals belonging to the second-g...

Quantitative trait loci (QTL) for domestication-related traits were identified in an interspecific F(2) population of eggplant (Solanum linnaeanum x S. melongena). Although 62 quantitative trait loci (QTL) were identified in two locations, most of the dramatic phenotypic differences in fruit weight, shape, color, and plant prickliness that distinguish cultivated eggplant from its wild relative ...

traits such as soluble solids content, fruit acidity, ph, fruit lycopene concentration, fruit beta-caroteneconcentration, and fruit xanthophyll concentration are very important to the tomato industry. in this study,quantitative trait loci (qtl) analysis of these traits was performed using a recombinant inbred line (ril)population derived from a cross between a tomato (lycopersiconesculentum mil...

One of the major determining factors in the price of market hogs today is backfat depth. Therefore, identification of regions of the genome affecting this trait could be very useful to the swine industry. A large resource population (n = 540) was developed by backcrossing F1 Meishan-White composite females to either Meishan or White composite boars. A genomic scan was conducted by genotyping al...

Several quantitative trait loci (QTL) mapping strategies can successfully identify major-effect loci, but often have poor success detecting loci with minor effects, potentially due to the confounding effects of major loci, epistasis, and limited sample sizes. To overcome such difficulties, we used a targeted backcross mapping strategy that genetically eliminated the effect of a previously ident...

Quantitative trait locus (QTL) analysis was performed to identify the chromosomal region controlling rice stripe virus (RSV) resistance in Japanese upland rice, Kanto 72. As a result, two QTLs were detected on chromosomes 2 and 11. Using near-isogenic lines possessing a single QTL (QTL-NILs) on chromosomes 2 and 11, the effects of two QTLs were evaluated. The target QTL regions were introduced ...

Linkage analysis involves performing significance tests at many loci located throughout the genome. Traditional criteria for declaring a linkage statistically significant have been formulated with the goal of controlling the rate at which any single false positive occurs, called the genomewise error rate (GWER). As complex traits have become the focus of linkage analysis, it is increasingly com...

An F2 Japanese quail population was developed by crossing two strains (wild and white) to map quantitative trait loci (QTL) for performance and carcass traits. A total of 472 F2 birds were reared and slaughtered at 42 days of age. Performance and carcass traits were measured on all of the F2 individuals. Parental (P0), F1 and F2 individuals were genotyped with 3 microsatellites from quail chrom...