The study aimed at the development of an HPLC method enabling the identification and determination of the content of selected compounds occurring in multicomponent veterinary preparations used in parasitic diseases. The studied compounds included: pyrantel embonate, fenbendazole, praziquantel, epsiprantel and febantel. Using the developed HPLC method, a good separation of the above compounds wa...

The efficacy of six anthelmintics against natural infections of Baylisascaris procyonis in raccoons (n = 7 per drug) was determined in a series of critical tests. The drugs were given via moist cat food as a single dose or once daily for three consecutive days. Raccoons treated with pyrantel embonate (1 x 20 mg base kg-1 bodyweight (bwt.)), ivermectin (1 x 1 mg kg-1 bwt.), moxidectin (1 x 1 mg ...

Pyrantel has been demonstrated (Bumbalo et al., 1969; Desowitz et al., 1970; Hsieh, 1971) to be effective for treatment of Ascaris, hookworm and Enterobuis. Oxantel has been shown (Zaman and Sabapaty, 1975; Garcia, 1976; Lee et al., 1976; Rim et al., 1976) to be effective against Trichuriasis. A combined Oxantel-pyrantel salts has been shown (Rim et al., 1975; Lim, 1978; Dissanaike, 1978; Cabre...

The study was undertaken to examine the effect of single and combined administration of dimethoate (an OP insecticide) and pyrantel embonate (an anthelmintic agent) on the concentration of reduced glutathione (GSH) and the activity of glutathione peroxidase (GPx) and glutathione reductase (GR) in rats. Dimethoate (Group I) was administered to rats at a dose of 1/10 LD50 for 5 consecutive days a...

Hookworm is one of the most common parasites in the world, but can be missed on stool examination. We report a 31-year-old man who was complaining of epigastric discomfort, with laboratory findings of iron-deficiency anemia and eosinophilia. He was found to be infected with hookworm (Ancylostoma duodenale), which was directly detected and retrieved from the duodenum with biopsy forceps during u...

BACKGROUND Second-generation antipsychotics (SGAs) represent an advance in the long-term management of schizophrenia. AIMS To review the available evidence concerning SGA long-acting injections (LAIs). METHOD A systematic review of the literature was conducted using PubMed. RESULTS Risperidone long-acting injection was the first licensed SGA-LAI compound and is effective in the long-term ...

The Hippo pathway is a signaling cascade recently found to play a key role in tumorigenesis therefore understanding the mechanisms that regulate it should open new opportunities for cancer treatment. Available data indicate that this pathway is controlled by signals from cell-cell junctions however the potential role of nuclear regulation has not yet been described. Here we set out to verify th...