نتایج جستجو برای: pyridoxine
تعداد نتایج: 1897 فیلتر نتایج به سال:
Vitamin B6 is essential for cellular functions and growth due to its involvement in important metabolic reactions. Humans and other mammals cannot synthesize vitamin B6 and thus must obtain this micronutrient from exogenous sources via intestinal absorption. The intestine, therefore, plays a central role in maintaining and regulating normal vitamin B6 homeostasis. Due to the water-soluble natur...
Pyridoxine-dependent epilepsy was recently shown to be due to mutations in the ALDH7A1 gene, which encodes antiquitin, an enzyme that catalyses the nicotinamide adenine dinucleotide-dependent dehydrogenation of l-alpha-aminoadipic semialdehyde/L-Delta1-piperideine 6-carboxylate. However, whilst this is a highly treatable disorder, there is general uncertainty about when to consider this diagnos...
In the current study, we investigated the inhibitory activity of pyridoxine, pyridoxal, and pyridoxamine, against various digestive enzymes such as α-glucosidases, sucrase, maltase, and glucoamylase. Inhibition of these enzymes involved in the absorption of disaccharide can improve post-prandial hyperglycemia due to a carbohydrate-based diet. Pyridoxal (4.14 mg/mL of IC50) had the highest rat i...
Three adult Beagle dogs given pyridoxine hydrochloride orally at a dose of 150 mg/kg body weight/day for about 100 days developed ataxia and had spastic, dysmetric leg movements. Ultrastructural alterations in the dorsal funiculus of the spinal cord were degeneration and loss of axons and myelin, and secondary changes of the myelin sheaths. Possible pathogenic mechanisms of pyridoxine neurotoxi...
l-tyrosine, b6 and folic acid are involved in biosynthesis of dopa and consequently dopamine. the aim of this study was to investigate the antiparkinsonian effect of these agents in perphenazine-induced catatonia in rats. murprogo method or scored muscular rigidity, which is induced by a phenothiazine, was used to evaluate the antiparkinsonian effect of these agents. a significant decrease in m...
The factors which govern the absorption of iron are not well understood. The current theory of iron absorption assigns to bodily need for iron the chief role in the regulation of iron absorption (1, 2). Conclusive evidence is needed, however, to demonstrate the correctness of such a view. In an earlier study from this laboratory (3), it was demonstrated that the high serum iron values and hemos...
The first naturally occurring form of vitamin B6 was isolated in 1938. It has the structure, confirmed by chemical synthesis (1939), of 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine (I; R = -CHzOH). The trivial name “pyridoxine,” proposed for this compound by P. GyGrgy, came into general use as a synonym for “vitamin Be.” Two other natural compounds possessing vitamin B6 activity, detected ...
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