نتایج جستجو برای: pyridinone
تعداد نتایج: 139 فیلتر نتایج به سال:
BACKGROUND: Numerous studies have shown that combining the indigenous fungal pathogen, Mycoleptodiscus terrestris (Gerd.) Ostazeski, hereafter referred to as Mt, with low doses of herbicides has excellent potential as an integrated strategy for long-term management of hydrilla and Eurasian watermilfoil (Myriophyllum spicatum L.) (Netherland and Shearer 1996; Nelson et al. 1998; Shearer and Nels...
Compounds modulating metabotropic glutamate type 2 (mGlu2) receptor activity may have therapeutic benefits in treating psychiatric disorders like schizophrenia and anxiety. The pharmacological and pharmacokinetic properties of a novel mGlu2 receptor-positive allosteric modulator (PAM), 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-2(1H)-pyridinone (JNJ-40411813/ADX71149) are described here. JNJ-4...
Benzamides and nicotinamides represent classes of drugs that have experienced an unusually broad spectrum of clinical development in a number of therapeutic areas [1]. One of their principal targets is the nuclear DNAbinding protein poly(ADP-ribose) polymerase-1 (PARP1), which is activated by nicks in DNA during inflammation, ischemia, neurodegeneration, and cancer therapy. When over-activated,...
UNLABELLED Many forms of organocomplexed gadolinium (Gd) contrast agents have recently been linked to a debilitating and a potentially fatal skin disease called nephrogenic systemic fibrosis (NSF) in patients with renal failure. Free Gd released from these complexes via transmetallation is believed to be the most important trigger for NSF. In this work, nanostructure silica materials that have ...
The understanding of the biotransformations of insulin mimetic vanadium complexes in human blood and its transport to target cells is an essential issue in the development of more effective drugs. We present the study of the interaction of oxovanadium(iv) with human serum albumin (HSA) by electron paramagnetic resonance (EPR), circular dichroism (CD) and visible absorption spectroscopy. Metal c...
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