Objective: The aim of the present study was to develop and evaluate the monolithic osmotic tablet (MOT) composed of the solid dispersion of ketoprofen (KETO), a poorly water-soluble drug. Solid dispersion technique is generally used for immediate release, as this maximizes the amount of drug absorbed. Sustained release may be obtained by combining solid dispersion technique with MOT so as to in...

Operando synchrotron powder X-ray diffraction deconvolutes support and metal nanoparticle changes during thermal deactivation of Ni/ZrO 2 methanation catalysts.

Physical or chemical interactions between drug product (DP) components can occur during manufacturing and/or upon storage; and may alter DP shelf life performance. In this work a new Powder X-ray Diffraction (PXRD) peak was observed in under accelerated storage conditions. Due to the complex matrix (including API, polymer, fillers, super disintegrant lubricant), it challenging pinpoint componen...

Sub-micrometer-sized CdS spheres were synthesized by hydrothermal and solvothermal reactions using Cd(NO3)2.4H2O and CH4N2S raw materials at a constant stoichiometric 1 : 2, Cd : S molar ratio. Various conditions such as solvent type (water and/or ethanol), reaction time and temperature were examined for the synthesis of the targets. The sy...

In this paper, three techniques to obtain capped magnetite nanoparticles were compared. In the formation of magnetite nanoparticles via the co-precipitation route, capping agents were introduced pre-, simultaneously with, or post-addition of the precipitating agent, ammonia. The amino acids L-glutamine and L-glutamic acid were used as the capping agents. Characterization via TEM, pXRD, EDX, and...

Fluid Catalytic Cracking (FCC) has traditionally been a key refining process in generating transportation fuels. Recently, the focus on FCC further intensified as it plays an increasingly important role generation of building blocks for petrochemical industry. Nickel is considered one most challenging contaminants and originates from Ni-containing compounds petroleum fractions, not only during ...

Abstract Background Cocrystallization is one of the crystal engineering strategies used to alter physicochemical properties drugs that are poorly water-soluble. Gliclazide (GLZ), an antidiabetic drug, belongs Biopharmaceutical Classification System class-II (low solubility and high permeability) has low bioavailability, resulting in poor therapeutic effects patients. Therefore, impart better bi...

Abstract The complete characteristics knowledge of clay minerals is necessary in the evaluation studies hydrocarbon reservoirs. Ten samples taken from two wells a heterogeneous clastic gas reservoir formation NE Iran were selected to conduct transmission Fourier transform infrared spectroscopy (FTIR) tests for mineralogy studies. FTIR analysis showed that there clear signs all samples. wavenumb...

Background and purpose: The aim of the work was to compare interactions three newly synthesized non-toxic starch derivatives, with varied anionic non-ionic functional groups methylene blue (MB) as a model cationic drug, selection derivative highest affinity MB. Experimental approach: native potato (SN), modified via acetylation (SM1), esterification crosslinking (SM2) (SM3), evaluated in MB ads...