Periodontal disease is the leading cause of tooth loss, which also a high-risk factor for other diseases including oral cancer and cardiovascular disease. Periodontitis one most common type periodontal diseases. Interleukin-1β (IL-1β) plays key role in pathogenesis periodontitis. However, mechanism how IL-1β produced during periodontitis still unclear. In present study, we found that human β-de...

Perisynaptic glial cells respond to neural activity by increasing cytosolic calcium, but the significance of this pathway is unclear. Terminal/perisynaptic Schwann cells (TPSCs) are a perisynaptic glial cell at the neuromuscular junction that respond to nerve-derived substances such as acetylcholine and purines. Here, we provide genetic evidence that activity-induced calcium accumulation in neo...

Mutations in human LPIN2 produce a disease known as Majeed syndrome, the clinical manifestations of which are ameliorated by strategies that block IL-1β or its receptor. However the role of lipin-2 during IL-1β production remains elusive. We show here that lipin-2 controls excessive IL-1β formation in primary human and mouse macrophages by several mechanisms, including activation of the inflamm...