PURPOSE Laser-targeted angiography has unique advantages over conventional angiography of the fundus. Its efficacy in visualizing choroidal neovascular membranes was tested in a rat model and compared to that of fluorescein angiography. METHOD Laser-targeted angiography was performed in rats with choroidal neovascularization (CNV) by injecting heat-sensitive carboxyfluorescein liposomes intra...

We describe a high-performance time-resolved fluorescence (HPTRF) spectrometer that dramatically increases the rate at which precise and accurate subnanosecond-resolved fluorescence emission waveforms can be acquired in response to pulsed excitation. The key features of this instrument are an intense (1 μJ/pulse), high-repetition rate (10 kHz), and short (1 ns full width at half maximum) laser ...

ALA: aminolevulinic acid BBL: broadband light IPL: intense pulse light Nd:YAG: neodymium-doped yttrium aluminium garnet PDT: photodynamic therapy INTRODUCTION Sarcoidosis is an inflammatory disease characterized by noncaseating epithelioid cell granulomas. Skin involvement is seen in approximately onequarter of patients. Multiple cutaneous variants in sarcoidosis include lupus pernio, Lofgren s...

The challenge in visualizing fast microscale fluid motion phenomena is to record high-quality images free of motion-blur. Here, we present an illumination technique based on laser-induced fluorescence which delivers high-intensity light pulses of 7 ns. The light source consists of a Q-switched Nd:YAG laser and a laser dye solution incorporated into a total internal reflection lens, resulting in...

BACKGROUND Keloids are abnormal wound responses characterised by excessive deposition of collagen and glycoprotein. They are both aesthetically and symptomatically distressing for most of the patients. There are reports of keloid management with pulsed dye laser (PDL), fractional carbon dioxide (CO2) laser and neodymium-doped yttrium aluminium garnet (Nd:YAG) laser individually and also in comb...

A new tool for imaging both scalar transport and velocity fields in liquid flows through microscale structures is described. The technique employs an ultraviolet laser pulse to write a pattern into the flow by uncaging a fluorescent dye. This is followed, at selected time delays, by flood illumination with a pulse of visible light which excites the uncaged dye. The resulting fluorescence image ...

The spectral narrowing of emission in the linear region of passively mode-locked lasers is thought to increase the final pulse duration obtained in the nonlinear mode-locking region. Properly adjusted Fabry— Perot interferometers were applied for partial suppression of natural mode-selection in mode-locked ruby [ 1,2] Nd-glass [3,4], and Nd—YAG lasers [5]. Pulse shortening factors between 1.5 a...