The antithetical regulation of cardiac α- and β-myosin heavy chain (MHC) genes by thyroid hormone (T(3)) is not well understood but appears to involve thyroid hormone interaction with its nuclear receptor and MHC promoters as well as cis-acting noncoding regulatory RNA (ncRNA). Both of these phenomena involve epigenetic regulations. This study investigated the extent that altered thyroid state ...

BACKGROUND Hyperthyroidism affects about 0.2%-2.7% of all pregnancies, and is commonly managed with antithyroid drugs (ATDs). However, previous studies about the effects of ATDs on congenital anomalies are controversial. Therefore, the present meta-analysis was performed to explore the risk of congenital anomalies in children exposed to ATDs in-utero. METHODS Embase, Pubmed, Web of Knowledge,...

OBJECTIVE To determine the level of agreement with the presumed diagnosis and long term clinical outcomes after antituberculous therapy (ATT) in a group of patients with presumed tuberculous uveitis (PTU) affecting the posterior segment. METHODS Retrospective case series. RESULTS A total of 17 patients with chronic refractory or newly diagnosed uveitis affecting the posterior segment were i...

Introduction: The role of brain tissues oxidative damage in learning and memory impairments has been well documented. It is also well known that thyroid hormones have a critical role for the brain functions. The purpose of this study was to investigate the role of brain tissues oxidative damage as a possible mechanism of deleterious effects of propylthiouracil (PTU) - induced hypothyroidism on ...

lead is known to be a potent neurotoxin that can cause seizure activity in humans and animals. also, epileptic type convulsion is a known complication of hypothyroidism. this study was performed to determine the effect of propylthiouracil (ptu)-induced hypothyroidism and chronic lead exposure on pentylenetetrazol (ptz)-induced kindling parameters. the test was carried out by using male albino r...

The response to methimazole [1-methyl-2-mercapto-imidazole (MMI)] therapy, 10 mg twice daily in 15 patients and propylthiouracil (P TU) therapy, 100mg twice daily in 10 patients with diffuse toxic goiter was evaluated in an area of iodine deficiency (Tehran). The mean free T4 index (FT4I) decreased from 22.7± 6.8 (± SD) to 10.8± 2.8 In MMI-treated, and from 25.1± 6.8 to 13.2± 2.1 in PTU-tr...

PTU-035 Table 1 Age and sex Endo diagnosis Endotherapy Co morbidity Outcome 30 days mortality Y/N

The effects of feeding of 6-propylthiouracil (6-PTU) and polyunsaturated fatty acids (PUFA) independently and in combination and administration (ip) of a single dose of triiodothyronine (T3) (2.5 microg/100 g body wt) along with feeding of 6-PTU and PUFA were studied in rat brain. Dopamine (DA), 5-hydroxytryptophan (5-HTP), serotonin (5-HT), 5-hydroxy indole acetic acid (5-HIAA), norepinephrine...

The title complex, [Ag3Br2(C25H22P2)3]Br·C7H8N2S, comprises a trinuclear [Ag3Br2(C25H22P2)3](+) unit, a Br(-) anion and one N,N'-di-methyl-thio-urea mol-ecule (ptu). Three Ag(I) ions are linked via two μ3-bridging Br atoms, leading to a distorted triangular bipyramid with an Ag⋯Ag separation range of 3.1046 (6)-3.3556 (6) Å. The triangular Ag3 arrangement is stabilized by six P atoms from three...