نتایج جستجو برای: ptk

تعداد نتایج: 1449  

Journal: :American journal of physiology. Heart and circulatory physiology 2005
Zuojun Ren Clive M Baumgarten

Regulation of swelling-activated Cl(-) current (I(Cl,swell)) is complex, and multiple signaling cascades are implicated. To determine whether protein tyrosine kinase (PTK) modulates I(Cl,swell) and to identify the PTK involved, we studied the effects of a broad-spectrum PTK inhibitor (genistein), selective inhibitors of Src (PP2, a pyrazolopyrimidine) and epidermal growth factor receptor (EGFR)...

Journal: :Oncology reports 2011
Johannes D Schultz Sarah Rotunno Philipp Erben J Ulrich Sommer Clemens Anders Jens Stern-Straeter Ralf-Dieter Hofheinz Karl Hörmann Alexander Sauter

Squamous cell carcinoma of the head and neck (HNSCC) is the most common neoplasm arising in the upper aerodigestive tract. Unfortunately, the survival for this type of cancer has not improved significantly in the past 25 years. To enhance the survival rate multimodal therapy regimens have been set up. In these regimens chemotherapy plays a pivotal role in the majority of advanced cases. Transme...

2002
NADEEM FAZAL WALID M. AL-GHOUL MEGAN J. SCHMIDT MASHKOOR A. CHOUDHRY MOHAMMED M. SAYEED Walid M. Al-Ghoul Megan J. Schmidt Mashkoor A. Choudhry

Fazal, Nadeem, Walid M. Al-Ghoul, Megan J. Schmidt, Mashkoor A. Choudhry, and Mohammed M. Sayeed. Lynand ERK-mediated vs. Ca2 -mediated neutrophil O2 responses with thermal injury. Am J Physiol Cell Physiol 283: C1469–C1479, 2002. First published June 20, 2002; 10.1152/ajpcell.00114.2002.—We evaluated the dependency of neutrophil O2 production on PTK-Lyn and MAPKERK1/2 in rats after thermal inj...

Journal: :Investigative ophthalmology & visual science 2002
Ashley Behrens Erlinda M Gordon Li Li Peng X Liu Zhenhai Chen Hongjun Peng Laurie La Bree W French Anderson Frederick L Hall Peter J McDonnell

PURPOSE To determine the in vivo efficacy and safety of a retroviral vector bearing an antiproliferative dominant negative mutant cyclin G1 (dnG1) construct, when used for the prevention of corneal haze after phototherapeutic keratectomy (PTK). METHODS For in vivo efficacy studies, a 6-mm-diameter, 150-microm-deep transepithelial PTK, performed with a clinical 193-nm ArF excimer laser (VISX S...

Journal: :Biochimica et biophysica acta 2013
Bhopal Mohapatra Gulzar Ahmad Scott Nadeau Neha Zutshi Wei An Sarah Scheffe Lin Dong Dan Feng Benjamin Goetz Priyanka Arya Tameka A Bailey Nicholas Palermo Gloria E O Borgstahl Amarnath Natarajan Srikumar M Raja Mayumi Naramura Vimla Band Hamid Band

Protein tyrosine kinases (PTKs) coordinate a broad spectrum of cellular responses to extracellular stimuli and cell-cell interactions during development, tissue homeostasis, and responses to environmental challenges. Thus, an understanding of the regulatory mechanisms that ensure physiological PTK function and potential aberrations of these regulatory processes during diseases such as cancer ar...

Journal: :Blood 2003
Karsten Spiekermann Ralf J Dirschinger Ruth Schwab Ksenia Bagrintseva Florian Faber Christian Buske Susanne Schnittger Louise M Kelly D Gary Gilliland Wolfgang Hiddemann

Activating mutations of the protein tyrosine kinase (PTK) FLT3 can be found in approximately 30% of patients with acute myeloid leukemia (AML), thereby representing the most frequent single genetic alteration in AML. These mutations occur in the juxtamembrane (FLT3 length mutations; FLT3-LMs) and the second tyrosine kinase domain of FLT3-TKD and confer interleukin 3 (IL-3)-independent growth to...

Journal: :Arthritis Research & Therapy 2003
Thomas Pap

ECM = extracellular matrix; FAK = focal adhesion-associated tyrosine kinase; PTP = protein tyrosine phosphatase; RA = rheumatoid arthritis; SF = synovial fibroblast; Src-PTK = src protein tyrosine kinase.

Journal: :Acta poloniae pharmaceutica 2013
Joanna Wawszczyk Arkadiusz Orchel Małgorzata Kapral Ludmiła Wéglarz

Phytic acid (IP6) is a major fiber-associated component of a diet physiologically present in human intestines. Studies showed that this phytochemical can modulate immune functions of intestinal epithelium through regulation of proinflammatory cytokines secretion but mechanisms underlying these cellular response to IP6 have weakly been examined, as yet. The aim of this study was to determine the...

Journal: :Glia 2008
James Haorah Kathy Schall Servio H Ramirez Yuri Persidsky

Blood-brain barrier (BBB) formed by brain microvascular endothelial cells (BMVEC) regulates the passage of molecules and leukocytes in and out of the brain. Activation of matrix metalloproteinases (MMPs) and alteration of basement membrane (BM) associated with BBB injury was documented in stroke patients. While chronic alcoholism is a risk factor for developing stroke, underlying mechanisms are...

2017
Wen-Shin Lee Carson K Lam Edward E Manche

PURPOSE The purpose of this study was to evaluate the long-term efficacy of phototherapeutic keratectomy (PTK) in treating epithelial basement membrane dystrophy (EBMD). METHODS Preoperative and postoperative records were reviewed for 58 eyes of 51 patients with >3 months follow-up (range 3-170 months) treated for EBMD with PTK after failure of conservative medical treatment at Byers Eye Inst...

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