BACKGROUND Severe forms of psoriasis can be complicated by systemic microvascular hyperpermeability. Vascular endothelial growth factor (VEGF) possesses potent vascular permeability activity. We suggest that VEGF enters the systemic circulation and acts on microvessels to mediate hyperpermeability. OBJECTIVES To quantify renal microvascular permeability and circulating VEGF concentration in s...

BACKGROUND To study the impact of psoriasis and features associated with psoriasis on classification and outcome in a population-based follow-up cohort of children with juvenile idiopathic arthritis (JIA). METHODS In all, 440 children with JIA were followed for a median of 8 years in a prospective Nordic population-based cohort study. Data for remission was available for 427 of these children...

BSA: body surface area HLA: human leukocyte antigen IL: interleukin PGA: physician global assessment Th: T helper INTRODUCTION Guttate psoriasis is an acute, eruptive form of psoriasis characterized by small, scaly papules and plaques. The exact immunopathogenesis of guttate psoriasis is unclear. However, this subtype of psoriasis shares several features with plaque psoriasis, including an asso...

OBJECTIVE This review focuses on the association of lithium treatment and psoriasis. The mechanism of action of lithium in causing psoriasis and the clinical presentation of psoriasis secondary to lithium treatment are considered. DATA SOURCES A search of the literature from 1949 to 2007 was performed using MEDLINE, with the following search terms: lithium, psoriasis, skin, dermatology, and p...

Background: Quality of life (QoL) assessment is becoming crucial in clinical trials, particularly with psoriasis. Objectives: The aim of this study was to evaluate QoL by the Moroccan version of the DLQI (Dermatology Life Quality Index) among psoriatic patients compared to vitiligo. Methods: This is a prospective study of patients aged 18 or older, who consulted at the dermatology clinic for ps...

Many of the molecular pathways associated with psoriasis pathogenesis are also involved in host defense mechanisms that protect against common pathogens. Candida can stimulate the production of cytokines that trigger or exacerbate psoriasis, and many systemic psoriasis treatments may put patients at increased risk for developing oral, cutaneous, and genitourinary candidiasis. Therefore, dermato...

The expression of beta 2 integrin CD11b on granulocytes and monocytes from patients with psoriasis vulgaris and pustular psoriasis was examined by flow cytometry. The amount of CD11b expressed on both granulocytes and monocytes was greater in 4 patients with pustular psoriasis than in 16 patients with psoriasis vulgaris. Its expression correlated with the development of pustules on the skin. No...

The International Psoriasis Council, a global nonprofit organization dedicated to innovation across the full spectrum of psoriasis, led a symposium to discuss the current state of psoriasis epidemiology and to introduce the vision and development of a Global Psoriasis Atlas. The symposium was held on 9 September 2015 at the 45th annual meeting of the European Society for Dermatological Research...

introduction: palmoplantar psoriasis could hardly be differentiated from chronic tylotic eczema both clinically and histologically. the most commonly used therapeutic options for palmoplantar psoriasis are long-term therapy with topical corticosteroids and local puva. frequently, it is a recalcitrant disease. we investigated the efficacy  and tolerability of the combination of topical calcipotr...

background: hyper ige syndrome (hies) is a rare primary immune deficiency, described as job`s syndrome characterized by increased serum levels of ige, eczema, recurrent cutaneous and pulmonary infections. in this paper, we presented a case of hyper ige syndrome.case presentation: a 16-year-old iranian boy presented with a one year history of skin lesions in knees and elbows was diagnosed of pso...