نتایج جستجو برای: psma
تعداد نتایج: 1762 فیلتر نتایج به سال:
BACKGROUND miR-15a and miR-16-1 have been identified as tumor suppressor genes in prostate cancer, but their safe and effective delivery to target cells is key to the successful use of this therapeutic strategy. RNA aptamer A10 has been used as a ligand, targeting prostate cancer cells that express prostate-specific membrane antigen (PSMA). Compared with A10, the binding of the second-generatio...
Herein, we developed a method to prepare monodisperse poly(styrene-co-maleic anhydride)@Ag (PSMA@Ag) core-shell microspheres with high surface charge intensity by using an in situ reduction method. In this method, ethylenediamine tetraacetic acid tetrasodium salt (Na4EDTA) was used as a reducing agent to promote the growth of Ag, and at the same time endowed the PSMA@Ag spheres with a surface c...
Prostate-specific membrane antigen (PSMA) is a promising target in prostate cancer. Recently, we started the first-in-human treatment with an α-radionuclide–labeled PSMA ligand. Although the case series is still ongoing, we here report in advance about two patients in highly challenging clinical situations who showed a complete response to 225AcPSMA-617 therapy. Methods: 68Ga-PSMA-11 PET/CT val...
PURPOSE Prostate-specific membrane antigen (PSMA) is a cell surface protein that is overexpressed in prostate cancer, including hormone-refractory and metastatic disease. Our goal in this study was to develop a series of PSMA-based imaging agents for clinical use. EXPERIMENTAL DESIGN We have synthesized and evaluated the in vivo biodistribution of two radiolabeled urea derivatives that have h...
PURPOSE In the context of prostate cancer (PCa) imaging, the aim of this study was to optimize (in vitro) the specificity and assess preclinically (in vivo) the tumor targeting properties of the 123I-scFvD2B antibody specific for prostate-specific membrane antigen (PSMA). EXPERIMENTAL DESIGN The 123I-labeling conditions of the antibody fragment scFvD2B, produced in an eukaryotic system under ...
We demonstrate the de novo fabrication of a biosensor, based upon virus-containing poly(3,4-ethylene-dioxythiophene) (PEDOT) nanowires, that detects prostate-specific membrane antigen (PSMA). This development process occurs in three phases: (1) isolation of a M13 virus with a displayed polypeptide receptor, from a library of ≈10(11) phage-displayed peptides, which binds PSMA with high affinity ...
مقدمه، سرطان پروستات شایع ترین سرطان موجود در مردان می باشد. استفاده از آنتی بادی در درمانهای انتخابی سرطان بسیار مورد توجه است. مهمترین فاکتور در درمان یا تشخیص، یافتن آنتی ژن های اختصاصی سرطان می باشد. آنتی ژن psma با توجه به افزایش آن در سرطان پروستات، گزینه مناسبی جهت آنتی بادی درمانی می باشد. نوع خاصی از آنتی بادی های شتری که vhh نام دارد، با توجه به کوچکی اندازه، دارای مزایای بسیار زیادی ...
BACKGROUND Overexpression of prostate-specific membrane antigen (PSMA) in tumor tissue and serum has been linked to increased risk of biochemical recurrence in surgically treated prostate cancer patients, but none of the studies have assessed its association with disease-specific mortality. METHODS We examined whether high PSMA protein expression in prostate tumor tissue was associated with l...
Background: 68Ga-PSMA-11, a novel PET radiopharmaceutical, is currently used for imaging of almost all prostate cancers. However, automatic radiolabeling procedures have been recommended. In this research, according to the chemical nature of the PSMA-11, manual, optimized and safe production of this radiopharmaceutical has been investigated and a standard method has been presented to achieve a ...
Purpose of the study: to present current data regarding challenges in treatment castration-resistant prostate cancer (CRPC) and relationship between CRPC expression prostate-specific membrane antigen (psma). Material Methods. The search for relevant sources was carried out Pubmed, elibrary, Medline databases. review included 43 publications, most which were published over past 5 years. Results....
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