Charged-particle beams consisting of protons or helium ions are a type of particulate radiation therapy. They contrast with conventional electromagnetic (i.e., photon) radiation therapy due to several unique properties including minimal scatter as particulate beams pass through tissue, and deposition of ionizing energy at precise depths (i.e., the Bragg peak). Thus, radiation exposure of surrou...

Charged-particle beams consisting of protons or helium ions are a type of particulate radiation therapy. They contrast with conventional electromagnetic (i.e., photon) radiation therapy due to several unique properties including minimal scatter as particulate beams pass through tissue, and deposition of ionizing energy at precise depths (i.e., the Bragg peak). Thus, radiation exposure of surrou...

Traversing proton beam-irradiated, mid/high-Z nanoparticles produce site-specific enhancement of X-ray photon-electron emission via the Coulomb nanoradiator (CNR) effect, resulting in a nano- to micro-scale therapeutic effect at the nanoparticle-uptake target site. Here, we demonstrate the uptake of iron oxide nanoparticles (IONs) and nanoradiator-mediated, site-specific thrombolysis without da...

Abstract Optically transparent lithium fluoride (LiF) thin films, thermally evaporated on Si(100) substrates, are under investigation as novel radiation detectors based radiophotoluminescence for imaging of the full Bragg curves proton beams produced by a linear accelerator therapy development at ENEA C.R. Frascati. Proton irradiation induces formation stable colour centres in LiF, amongst whic...

Alpha-particle emitter labeled monoclonal antibodies are being actively developed for treatment of metastatic cancer due to the high linear energy transfer (LET) and the resulting greater biological efficacy of alpha-emitters. Our knowledge of high LET particle radiobiology derives primarily from accelerated heavy ion beam studies. In heavy ion beam therapy of loco-regional tumors, the modulati...

Ions provide a more advantageous dose distribution than photons for external beam radiotherapy, due to their so-called inverse depth dose deposition and, in particular a characteristic dose maximum at their end-of-range (Bragg peak). The favorable physical interaction properties enable selective treatment of tumors while sparing surrounding healthy tissue, but optimal clinical use requires accu...

We study the spatial distributions of β-activity produced by therapeutic beams of He and C ions in various tissue-like materials. The calculations were performed within a Monte Carlo model for Heavy-Ion Therapy (MCHIT) based on the GEANT4 toolkit. The contributions from positronemitting nuclei with T1/2 > 10 s, namely 10,11C, N, 14,15O, 17,18F and P, were calculated and compared with experiment...

We propose a Gaussian sampled fiber Bragg grating for multi-parameter sensing system. The sampled fiber Bragg grating combines the characteristics of fiber Bragg grating and long period grating. The transfer matrix method has been used to obtain the transmission spectrum of the grating. The shifts in narrowband loss peak and broadband loss peak in the transmission spectrum have been utilized to...

One of the drawbacks Intensity Modulated Radiation Therapy (IMRT) technique is that absorbed dose in healthy tissue relatively high. Proton beam has characteristics can compensate for these drawbacks. The Bragg peak characteristic a proton allows administration high radiation doses to target organ only. Non-Small Cell Lung Cancer (NSCLC) cases are located vicinity many vital organs, so exceed c...