PURPOSE To determine whether radiation necrosis can be differentiated from residual/recurrent tumor by proton MR spectroscopy. METHODS We studied the effects of interstitial brachytherapy on the brains of healthy monkeys and in humans with glioblastoma multiforme. The effects of radiation therapy on normal brain tissue in monkeys were assessed with sequential proton MR spectroscopic studies 1...

A number of studies have demonstrated that a room temperature proton irradiation may not be sufficient to provide an accurate estimation of the impact of the space radiation environment on detector performance. This is a result of the relationship between defect mobility and temperature, causing the performance to vary subject to the temperature history of the device from the point at which it ...

Chemical exchange (CE) sensitive MRI contrast acquired with an off-resonance irradiation pulse is affected by other relaxation mechanisms, such as longitudinal and transverse relaxations. In particular, for intermediate CEs, the effect of transverse relaxation often dominates CE contrast. Since water relaxation rates can change significantly in many pathological conditions or during physiologic...

Chemical exchange saturation transfer (CEST) imaging provides a unique contrast through the exchange between solute protons and bulk water protons 1. It can detect tissue acidosis and elevated protein content in acute ischemia and animal tumor models 2,3. Conventionally, a continuous wave (CW) RF pulse is applied at the solute proton frequency and the saturation is transferred to the bulk water...

Proton detection has attracted immense interest recently, owing to the increasing demands for applications in physics, medicine, and space. However, proton detectors suffer from a general problem of performance degradation caused by irradiation-induced defects over long-term operation. Herein, we report detector based on methylammonium lead tribromide (MAPbBr3) perovskite single crystal, which ...

Inadequate research exists regarding testing of a ventricular assist device (VAD) for susceptibility to radiation damage. Specifically, minimal data are available to radiation oncologists prescribing treatment plans for patients with an implanted VAD. As the number of implanted devices increases, patients requiring radiation at tissue sites near or at the device will increase. The purpose of th...

Proton beam irradiation is a form of advanced radiotherapy providing superior distributions of a low LET radiation dose relative to that of photon therapy for the treatment of cancer. Even though this clinical treatment has been developing for several decades, the proton radiobiology critical to the optimization of proton radiotherapy is far from being understood. Proteomic changes were analyze...

A comprehensive study on the effects of energetic protons on carbon fiber composites and compounds under consideration for use as low-Z pion production targets in future high power accelerators and lowimpedance collimating elements for intercepting TeV-level protons at the Large Hadron Collider has been undertaken addressing two key areas namely thermal shock absorption and resistance to irradi...

We demonstrate a timed explosive drug release from smart pH-responsive hydrogels by utilizing a phototriggered spatial pH-jump reaction. A photoinitiated proton-releasing reaction of o-nitrobenzaldehyde (o-NBA) was integrated into poly(N-isopropylacrylamide-co-2-carboxyisopropylacrylamide) (P(NIPAAm-co-CIPAAm)) hydrogels. o-NBA-hydrogels demonstrated the rapid release of protons upon UV irradia...

Diamond is used as detector material in high energy physics experiments due to its inherent radiation tolerance. The RD42 collaboration has measured the tolerance of chemical vapour deposition (CVD) diamond against proton, pion, and neutron irradiation. Results this study are summarized article. detectors can be further enhanced by using a 3D electrode geometry. We present preliminary results p...