Gentamicin (GEN) is an aminoglycoside antibiotic with a potent antibacterial activity against a wide variety of bacteria. However, its poor cellular penetration limits its use in the treatment of infections caused by intracellular pathogens. One potential strategy to overcome this problem is the use of particulate carriers that can target the intracellular sites of infection. In this study GEN ...

Clinical observations indicate that impairment of venous and lymphatic microcirculation is a major complication of orthopedic surgery. Usually it is older patients with certain risk factors that are affected. The symptoms are generally present after knee or hip arthroplasty, but they may occur even after less invasive procedures performed on patients with musculo-skeletal trauma, or as complica...

In this study, paclitaxel loaded poly( L-lactic acid) (PTX-PLLA) microparticles were prepared using solution enhanced dispersion by supercritical CO2(SEDS) technique. This supercritical antisolvent technique offers the advantage of negligible organic solvent residua in the drug loaded microparticles. Scanning electron microscopy (SEM) showed that microparticles exhibited rather spherical shape ...

background: in vitro simulation of developmental processes is an invaluable tool to shed light on the intrinsic mechanism of developmental biosystems such as central nervous system in mammals. chick somites have been used to simulate the neural differentiation of human neural progenitor cells. in the present study, we aimed to indicate whether somites have the ability to express required neural...

Abstract Exploring the use of seedless blackcurrant pomace, a fibre-rich by-product juice pressing, in foods is favourable due to its nutritional profile but also for economic and sustainability aspects. Current applications are limited products which rapid fibre swelling, high water solubility or low sedimentation not essential. In this study, functional properties pomace were modified by ther...

Bioflavonoids such as hesperidin and hesperetin anticancer antioxidant agents are widely used in the formulation of many herbal drugs. Recently, promising evidence for prevention treatment COVID 19 using these compounds has been reported. Unfortunately, often insoluble aqueous media have low stability gastric acid environment. These factors reduced bioavailability related oral dosage forms dige...

The aim of this study was to improve wettability and dissolution rate of a poorly water-soluble drug, cilostazol, using the supercritical antisolvent (SAS) process. The solid state of particles precipitated from dichloromethane containing additives, including poloxamer 188, poloxamer 407, TPGS 1000, Gelucire 44/14 and Gelucire 50/13, in supercritical CO(2) medium were characterized by different...

The phytochemical resveratrol has undergone extensive preclinical investigation for its putative cancer chemopreventive properties. Low systemic availability of the parent compound due to rapid and extensive metabolism, may confound its usefulness as a potential agent to prevent malignancies in organs remote from the site of absorption. Micronization allows increased drug absorption, thus incre...

In this study, we investigated the predictive indices for hypoglycemic effect of physically modified fibers. Micronization, ultrasonic, microwave and extrusion cooking treatments were applied to defatted rice bran dietary fibers to get modified defatted rice bran dietary fiber. The effects of physical treatments, pH and time of digestion, on the water binding Capacity (WBC), Swelling Capacity (...

a sweet water-soluble protein that reminds stable over wide ranges of temperature and ph, brazzein has various applications. its tastes like cane sugar but have no calories. however, the extraction of brazzein from its natural source is expensive and not applicable. in this study we used recombinant dna technology to provide an alternative option for cheaper mass production of brazzein. a brazz...