Introduction: D-galactose (D-gal) is well known as an appropriate agent to induced aging effects in the in vivo and in vitro models. In the present study, we selected crocin, the main constituent of Crocus sativus L. (Saffron), against D-gal cytotoxicity in human neuroblastoma SH-SY5Y cells. Materials and Methods:  Cells were pretreated with crocin (25-500 µM) for 24 h and then expos...

trr14 is a novel protein important in trehalose (α-d-glucosyl-[1,1]-α-d-glucopyranoside) signaling in arabidopsis. in this research, we provided evidences to demonstrate that trr14 plays role in arabidopsis responses to salt and drought stress. the transgenic arabidopsis plants over-expressing trr14 under the control of camv 35s promoter were generated. transformed lines showed higher transcrip...

Background and purpose: Vitamin D deficiency has been shown to be linked to evolution of ischemic stroke, but the data regarding the association between stroke severity and vitamin D level is scarce. Materials and methods: Patients with first-ever acute ischemic stroke in the middle cerebral artery (MCA) territory within 7 days after the stroke were recruited. The control group included age an...

Background Given the relationship of vitamin D deficiency with insulin resistance syndrome as the component of polycystic ovary syndrome (PCOS), the main aim of this study was to compare serum level of 25- hydroxyvitamin D [25(OH)D] between PCOS patients and normal individuals. MaterialsAndMethods A cross sectional study was conducted to compare 25(OH)D level between117 normal and 125 untreated...

H invasive pancreatic tumors are often recognized in late stages due to a lack of clear symptoms and pose major challenges for treatment and disease management. Broad-band Protein Kinase D (PKD) inhibitors have recently been proposed as additional treatment option for this disease. PKDs are implicated in the control of cancer cell motility, angiogenesis, proliferation and metastasis. In particu...

Infectious bursal disease virus (IBDV) is the causative agent of Gumboro disease, an infectious disease of global economic importance in poultry. Structural protein VP2 of IBDV is the most frequently studied protein due to its significant roles in virus attachment, protective immunity, and serotype specificity. The objective of the present study was to improve the expression of hypervariable re...

Objective: The current study was conducted to compare the effect of 150,000 and 300,000 IU of vitamin D on the healing status of diabetic foot ulcer among the patients with diabetes. Materials and Methods: This randomized clinical trial was carried out on 47 patients with diabetic foot ulcer and vitamin deficiency during four weeks follow-up. The patients were randomly assigned into two groups...

this experiment was conducted to evaluate the effect of different levels of crude protein and threonine on performance, carcass characteristics and immune system of broiler chickens during starter (7-24) and grower (25-42) periods. a total of 288 male broiler chicks of ross 308 strain were used in a completely randomized design with factorial arrangement (2×4) with three replicates in each trea...

Clinical data showed consumption of buckwheat played a very positive role in the relief of diabetes and its complications. The purpose of this study was to explore the effects and mechanisms of the overall flavonoids from buckwheat flowers and leaves (TFBFL) on renal damage in type 2 diabetes mellitus (T2DM) rats. Seventy male Wistar rats were selected. Ten rats were randomly allocated into a n...

In this study the programmed cell death (apoptosis) of human neutrophilic granulocytes was investigated in the presence and absence of fetal calf serum (FCS), cycloheximide and actinomycin-D. The results show that when FCS is omitted from cultures, apart from a decrease in viability, the percentage of apoptotic cells and DNA fragmentation increases. Apoptosis is accelerated in serum withdra...