Prostate cancer is the most prevalent cancer found in men above the age of fifty years and is frequently diagnosed in men between 45 and 89 years of age with a median age of 72 years. This work was undertaken to assess oxidative stress and antioxidant status in patients with carcinoma of prostate. Erythrocyte ascorbic acid and plasma vitamin E levels were estimated in patients with carcinoma of...

Objective(s): Apoptotic effect of apoptin has been demonstrated in numerous studies. However, its tumor specificity has been questioned by some reports. The aim of this study was to confine the expression of apoptin in the prostate tumor cells by inducing its gene expression under the control of a chimeric enhancer composing of prostate-specific membrane antigen (PSMA) and prostate-specific ant...

In a series of 68 patients suffering from carcinoma of the prostate, plasma fibrinolytic activity has been found to be similar to that in control groups. Some comments have been made on the problem of fibrinolysis and bleeding associated with carcinoma of the prostate, with the suggestion that the part played by fibrinolysis has been over-emphasized.

MicroRNAs (miRNA) are small, endogenously expressed noncoding RNAs that negatively regulate expression of protein-coding genes at the translational level. Accumulating evidence, such as aberrant expression of miRNAs, suggests that they are involved in the development of cancer. They have been identified in various tumor types, showing that different sets of miRNAs are usually deregulated in dif...

BACKGROUND Mitochondria play crucial roles in cell signaling events, interorganellar communication, aging, cell proliferation and apoptosis, and mitochondrial impairment has been shown to accelerate or modulate cancer progression. Ubiquitous mitochondrial creatine kinase (uMtCK) is predominantly localized in the intermembrane space of mitochondria and catalyzes the reversible exchange of high-e...

Adenosquamous carcinoma (ASC) and sarcomatoid carcinoma (SC) of the prostate are rare, but highly aggressive tumors. The occurrence of mixed carcinomas in the prostate is even more rarely reported. The present study reports the case of a 62-year-old male who was diagnosed with prostatic adenocarcinoma accompanied by multiple bone metastases, as shown by a needle biopsy and skeletal computed tom...

Renal-type clear cell carcinoma (RTCCC) of the prostate is a rare form kidney cancer that infrequently reported in literature. Here we describe case an 81-year-old male patient with hard, immovable mass on his enlarged prostate, which was discovered through digital rectal examination. His prostate-specific antigen (PSA) level 23.01 ng/ml, and bone multi-slice computed tomography scans re...

Between 2% and 9% of malignant tumours are metastasizing to the skin. Cutaneous metastases from carcinoma of the prostate occur infrequently. Their presence is associated with poor prognosis. We report the case of a 65-year-old man with carcinoma of the prostate, presenting multiple metastases in the scrotal skin region.

In this case report, we describe a patient with an uncommon presentation of disseminated prostate carcinoma. Initial presentation could mimic tuberculosis or hematological malignancy. The literature is reviewed for this kind of presentation. Furthermore, the value of immuno-histochemical stains in relation to prostate carcinoma is discussed.

www.amepc.org/tau © Translational Andrology and Urology. All rights reserved. Professor Christian G. Stief (Figure 1) is the Director of the Urological Clinic and Department, Grosshadern Campus, Munich University Hospital. His main fields include smooth muscle pharmacology, bladder carcinoma and reconstructive surgery. His current interests focus on laser in prostate and bladder carcinoma, lase...