preoperative gleason score (gs) obtained from trans rectal ultra sonography (trus) is the most common grading system to evaluate the appropriate treatment for patients with clinically localized prostate cancer. but this method showed upgraded and downgraded results in comparison to gleason score obtained from radical prostatectomy. the current study aimed to determine clinical or pathological v...

discoidin domain receptor (ddr) is a new member of the receptor tyrosine kinase family. there are two isoforms of discoidin domain receptor (ddr), ddr1 and ddr2. these receptors play a major role in the adhesion, motility and cell proliferation. due to the important role of ddr2 in the development of tumor extension, this receptor is pivotal in the field of carcinogenesis. the aim of this study...

background : a single nucleotide variation within  atechol-o-methyl transferase (comt) gene may alter the comt enzyme activity level. polymorphism of val158met in the comt gene has been related to malignancy. in this regard, a study was carried out to find a possible association between the comt gene polymorphism in patients with sporadic prostate cancer (pca) and benign prostatic hyperplasia (...

Cancer is among the leading causes of death and an important barrier to improving life expectancy globally. Prostate cancer second most common in men worldwide. The detection biomarkers body fluids key topic for diagnosis prognosis prostate cancer. Despite advances methods, therapeutic agents new biomarkers, remains a serious challenge. Prostate-specific antigen (PSA) widely recognized as bioma...

we report our experience with 124 patients were referred 70 our urology clinic in sina hospital for urinary retention. serum psa analyzed by using a monoclonal assay. all patients underwent digital rectal examination. the patients devided in 3 groups: group 1 (87 men) with a serum psa level less than 4 ng/ml, group 2 (26 men) with a serum psa level 4-10 ng/ml and group 3 (11 men) with a serum p...

Background: Benign prostatic hyperplasia (BPH) is the most common benign tumor in men. The etiology of BPH is still unresolved and multiple systems are likely to be involved. The effects of diabetes on urinary system are a risk factor for BPH. We then assessed the effects of diabetes on the parameters related to BPH, especially weight and volume. Methods: This study was conducted on patients...

Background: To correct patient positioning errors (setup errors) during prostate cancer treatment using EPID and fiducial gold markers, to improve the accuracy of the dose delivery in these patients. Materials and Methods: Fifteen patients with localized prostate carcinoma after implantation of fiducial gold markers in their prostate gland underwent the five-field IMRT planning technique. The p...

68Ga Prostate-specific membrane antigen (PSMA) is an increasingly popular radiopharmaceutical tracer in prostate cancer and is becoming increasingly researched in other cancers such as breast cancer, renal cell carcinoma, glioblastoma multiforme, among others. Cholangiocarcinoma is the second most common primary hepatic malignant tumor; it is an aggressive tumor with a 5-year surviva...

Prostate cancer is the most commonly diagnosed and second leading cause of mortality in men Western World. In initial stages, prostate dependent on androgens for growth which basis androgen ablation therapy. The effects are mediated by Androgen Receptor (AR). Therefore, studies focus identification AR-regulated genes that also highly expressed prostate. STAMP family STAMP1/STEAP2 STAMP2/STEAP4 ...