A 72-year-old male was admitted with painful swelling of his left arm. Physical examination revealed supraclavicular lymphadenopathy with swollen left arm and a stony-hard prostate on rectal examination. Routine blood tests were normal. Doppler test showed deep vein thrombosis in the left arm. Tomography of chest, abdomen and pelvis showed generalized lymphadenopathy, suggesting lymphoma. Biops...

OBJECTIVES To determine whether lower serum prostate-specific antigen (PSA) concentration in obese men is caused by plasma hemodilution and/or decreased serum testosterone levels. METHODS A sample of 413 men, from 45 to 75 years old, were randomly selected for the study among those who participated in prostate cancer screening at 2 urban urology practices in Argentina and Puerto Rico. Weight,...

Positive family history is a significant risk factor for prostate cancer. Improved knowledge of the epidemiology and molecular basis of hereditary prostate cancer has led to a need for counseling and clinical follow-up for men with a positive family history of prostate cancer. However, very little information is available on the efficacy of early screening procedures, such as serum prostate-spe...

P antigen (PSA) is a serine protease produced by the prostate gland at very high concentrations. PSA is secreted into the seminal plasma in high concentrations (0.5 to 5 g/L), where it plays a role in semen liquefaction. The retrograde release of PSA into the bloodstream is a rare event in young, healthy men. It occurs with a frequency of less than one PSA molecule per million secreted PSA mole...

The rise in incidence has been due to use of the blood serum test, Prostate Specific Antigen (PSA), as a screening test both formally in the USA and Europe, and informally in the UK. However, PSA is false positive-prone (7 out of 10 men in this category will still not have prostate cancer) and false negative-prone (3 out of 10 men with prostate cancer have no elevation in PSA). If a man has a r...

OBJECTIVES The ratio between free and total prostate-specific antigen (PSA) in serum (F/T ratio) was shown to improve the differentiation between prostate carcinoma and benign conditions in selected series of patients. In this study the F/T ratio was analyzed for its ability to improve the specificity of total serum PSA, digital rectal examination (DRE), and transrectal ultrasonography (TRUS) f...

background defining the optimal prostate-specific antigen threshold to identify the patients at the highest risk of prostate cancer has always been a controversial issue. objectives this study aims to analyze the diagnostic value of psa and also evaluate the relationship between psa (prostate-specific antigen) and bmi (body mass index) as well as psa and prostate size and volume in asymptomatic...

Prostate cancer has come to share the oncological centrestage among male cancers. The availability of Serum Prostate Specific Antigen, PSA, as a marker has encouraged it's use to diagnose both cancer and cancer recurrence. Some clarity is required about its precise role in clinical practice. The available literature on Prostate Specific Antigen was reviewed; Articles were reviewed for content, ...

Wisteria floribunda agglutinin (WFA) preferably binds to LacdiNAc glycans, and its reactivity is associated with tumor progression. The aim of this study to examine whether the serum LacdiNAc carrying prostate-specific antigen-glycosylation isomer (PSA-Gi) and WFA-reactivity of tumor tissue can be applied as a diagnostic and prognostic marker of prostate cancer (PCa). Between 2007 and 2016, ser...

PURPOSE To investigate whether hospitalization influences serum prostate-specific antigen (PSA) values. MATERIALS AND METHODS Transrectal ultrasound-guided prostate biopsies were performed for detecting prostate cancer in 2,017 patients between February 2001 and April 2011 at Ajou University Hospital. Of those patients, 416 patients who were hospitalized for prostate biopsies, whose serum PSA...