This experiment attempts to use NeuroEvolution of Augmenting Topologies (NEAT) create a Multiagent System that coevolves cooperative learning agents with a learning task in the form of three predators hunting the prey. Since the prey is hardcoded in a way that eludes the nearest predator, methods to capture the prey elude supervised learning techniques, i.e. cooperation is required to succeed. ...

Current techniques for single nucleotide polymorphism (SNP) detection require tedious experimental procedures and expensive and sophisticated instruments. In this study, a visual genotyping method has been successfully established via combining ARMS-PCR with gold magnetic nanoparticle (GoldMag)-based lateral flow assay (LFA) and applied to the genotyping of methylenetetrahydrofolate reductase (...

AS1411 is a G-rich aptamer that forms a stable G-quadruplex structure and displays antineoplastic properties both in vitro and in vivo. This oligonucleotide has undergone phase 2 clinical trials. The major molecular target of AS1411 is nucleolin (NCL), a multifunctional nucleolar protein also present in the cell membrane where it selectively mediates the binding and uptake of AS1411. Cell-surfa...

In this paper, we present an effective and efficient diagnosis system based on particle swarm optimization (PSO) enhanced fuzzy k-nearest neighbor (FKNN) for Parkinson’s disease (PD) diagnosis. In the proposed system, named PSO–FKNN, both the continuous version and binary version of PSO were used to perform the parameter optimization and feature selection simultaneously. On the one hand, the ne...

The aim of the present study was to analyze the relationship between aberrant human mutL homolog 1 (hMLH1) expression and clinicopathological parameters of patients with sporadic colorectal cancer, and to explore the prognostic effect of aberrant hMLH1 expression in these patients. The relationship was measured by chi-square test and Fisher's exact test. Survival analysis was performed with Kap...

A dramatic increase in bacterial resistance towards currently available antibiotics has raised worldwide concerns for public health. Therefore, antimicrobial peptides (AMPs) have emerged as a promisingly new group of therapeutic agents for managing infectious diseases. The present investigation focusses on the isolation and purification of a novel bacteriocin from an indigenous sample of cow mi...

Short cell-type specific promoter sequences are important for targeted gene therapy and studies of brain circuitry. We report on the ability of short promoter sequences to drive fluorescent protein expression in specific types of mammalian cortical inhibitory neurons using adeno-associated virus (AAV) and lentivirus (LV) vectors. We tested many gene regulatory sequences derived from fugu (Takif...

BACKGROUND AND THE PURPOSE OF THE STUDY Layer-by-layer (LbL) deposition of polyelectrolytes (PEs) has received a great attention in the area of drug delivery due to its simplicity and versatility. This research was aimed to develop multilayered microcapsules through LbL deposition of chitosan (CHI) and sodium alginate (NaALG) and utilize them as vehicle for controlled delivery of isoniazid (INH...

OBJECTIVE T20 (Enfuvirtide), which is a 36-residue peptide derived from the C-terminal heptad repeat (CHR) of gp41, is the only clinically available HIV-1 fusion inhibitor, but it easily induces drug resistance, which calls for next-generation drugs. DESIGN We recently demonstrated that the M-T hook structure can be used to design a short CHR peptide that specifically targets the conserved gp...

Automatic prediction of articulatory movements from speech or text can be beneficial for many applications such as speech recognition and synthesis. A recent approach has reported stateof-the-art performance in speech-to-articulatory prediction using feed forward neural networks. In this paper, we investigate the feasibility of using bidirectional long short-term memory based recurrent neural n...