The objective of the present investigation was to develop and evaluate a contraceptive vagino-adhesive propranolol hydrochloride gel. To achieve this, various mucoadhesive polymers including guar gum (1-4% w/w), sodium alginate (4-7% w/w), xanthan gum (2-5% w/w ), HPMC 4000 (3-5% w/w), Na CMC (4-7% w/w), carbomer 934 and carbomer 940 both in the range of 0.5-2.0% w/w, were dispersed in an aq...

THIS paper reviews evidence that the foetus plays a vital role in determining gestation at labour. The hypothesis was not the keystone of our work initially, but evidence of foetal regulation of the myometrium became increasingly apparent during the course of studies on uterine contractility in human pregnancy. Work on induction of labour (Turnbull & Anderson, 1967, 1968a, b) made us aware of t...

Hydrophilic matrices are of utmost interest for oral prolonged release drugs. However, they show decreasing rate over time, mainly due to lengthening the diffusional pathway across gel formed upon glass-rubber transition polymer. Therefore, achievement zero-order kinetics, which could reflect in constant drug plasma levels, is still an open issue. With aim improving performance hydroxypropyl me...

Although post-term pregnancy is associated with an increased incidence of fetal distress, oligohydramnios, fetal macrosomia, fetal dysmaturity, and perinatal mortality, as many as 80% of post-term fetuses appear completely normal. The authors of this article discuss the three sub-groups of post-term pregnancies, and deal with the diagnosis and antepartum and intrapartum management of the condit...