In situ hybridisation and immunohistochemical studies were conducted on six surgically excised subretinal membranes of proliferative vitreoretinopathy to investigate whether displacement of retinal pigment epithelial and glial cells to subretinal membranes was associated with fibronectin production by the subretinal membrane cells. Fibronectin messenger RNA (mRNA) and fibronectin immunoreactivi...

Proliferative vitreoretinopathy (PVR) is a vision-threatening disease and a common complication of surgery to correct rhegmatogenous retinal detachment (RRD). Several models of the pathogenesis of this disease have been described with some of these models focusing on the role of inflammatory cells and other models focusing on the role of growth factors and cytokines in the vitreous which come i...

TITLE: HUMAN FIBROBLASTS PRODUCE AN OPTIMAL PVR EXPERIMENTAL MODEL. AUTHORS: GRACIA-MARTIN M.C., LIBERT J. AFFILIATION: Senior research fellow, Or. Gracia-Martin M.C Prof and Head of Dep., Or. Libert J. Dep. Ophthalmology St. Pierre Hosp., Brussels ABSTRACT: Purpose. Complex tractional retinal detachments show a low percentage of succesful reattachment, due to the development of oroliferative v...

Purpose This study aimed to investigate the effect of OM-101 on the fibrotic response occurring in proliferative vitreoretinopathy (PVR) in an animal model. Methods Antifibrotic effect of OM-101 was investigated in vivo. As control, eight weeks old c57black mice underwent intravitreal injection with Hepes (group A) or dispase (0.3 units), to induce retinal detachment (RD) and PVR. The dispase...

BACKGROUND To evaluate the postoperative results and efficacy of retinectomy in the treatment of severe proliferative vitreoretinopathy (PVR). METHODS The study involved 38 individuals with rhegmatogenous retinal detachment initially diagnosed with PVR grade C3 who had undergone pars plana vitrectomy combined with scleral buckle and silicone oil as a tamponade. A standard three-port pars plan...

Introduction: We report two cases proliferative vitreoretinopathy that occurred as complication of degenerative retinoschisis. Case Series: Two patients; a male and a female with vitreo-retinal hemorrhage seen in our clinic were evaluated and retinoschisis found as the only cause of the bleeding. Both were treated with Argon barrier photocoagulation which arrested the hemorrhage and resolved th...