The process of designing progressive dies can be complex, tedious, time-consuming, and error-prone, which significantly impact the development period design quality. This paper presents a systematic methodology that includes planning automated die structure. A super model (SPM) is presented as output structure input Subsequently, parametric template based on deformation feature geometry (DFPG) ...

Clinical decision analyses use time horizons that vary from hours to the patient’s entire life. Analyses of decisions with a lifetime horizon commonly use Markov models, which simulate the patient’s lifespan by dividing it into equal periods (cycles). At each cycle, the model exposes a hypothetical cohort to the competing hazards of normal aging and of the disease in question (disease-specific ...

A machining manipulator is subject to mechanical interaction with the object being processed. The robot performs the task in constrained work space. In constrained tasks, one is concerned with not only the position of the robot end-point, but also the contact forces, which are desired to be accommodated rather than resisted. Therefore, interaction force needs to be considered in designing and c...

The lifetime prevalence of major depressive disorder is 16.5% and, each year, 800 000 individuals worldwide die as a result of suicide, a high proportion of whom suffered from severe depression. Even with treatment, 20% of patients experience chronic symptoms, meaning that major depressive disorder accounts for a greater number of years lived with disability than any other illness. A combinatio...

Die less explosive forming of circular plates is one of the most useful methods in the industries especially chemical applications. Manufacturing of large vessel's head, multilayer rings and some parts of heat exchangers are the example of applying this method. Many theoretical and experimental researches about examining the explosive forming of simple and single layer plate have been done. The...

The Multi-DOF forceps manipulator we developed has two additional DOF of bending on the tip of forceps, and provides new surgical fields and techniques for surgeons. The most remarkable characteristics of the prototype described in this paper are: 1) the small diameter and the small radius of curvature of bending; 2) the confirmation of perfect cleanness and sterilization of this manipulator. I...

Abstract A new process combination route consisting of additive manufacturing (AM) with a subsequent forming operation is proposed. The has the opportunity to increase efficiency AM up 360%. Stainless steel 316L sheets different core structures (similar sandwich sheets) are produced by AM, characterized, and formed in die bending operation. characteristics this novel semi-finished product can b...

The most common pediatric mitochondrial disease is Leigh syndrome, an episodic, subacute neurodegeneration that can lead to death within the first few years of life, for which there are no proven general therapies. Mice lacking the complex I subunit, Ndufs4, develop a fatal progressive encephalopathy resembling Leigh syndrome and die at ≈60 d of age. We previously reported that continuously bre...