We are pleased to present a series of Annotated Classics celebrating 40 years of exciting biology in the pages of Cell. This installment revisits “Genetic Control of Programmed Cell Death in the Nematode C. elegans” by Hilary M. Ellis and H. Robert Horvitz. Here, David Vaux comments on the work that first demonstrated that cell death was controlled by a genetic program by identifying genes that...

During Drosophila development, the steroid hormone ecdysone plays a key role in the transition from embryo into larva and then into pupa. It is during larval-pupal metamorphosis that extensive programmed cell death occurs to remove large obsolete larval tissues. During this transition, ecdysone pulses control the expression of specific transcription factors which drive the expression of key gen...

A programmed audiovisual introduction to a large obstetric-gynecologic clinic was developed for and evaluated b y nursing students w h o spent one or two weeks in the facility. This orientation is geared toward active learning and progress at each individual’s rate. Data show that this orientation is an effective and efficient substitute for faculty presentation of repetitive information. In si...

Morphological Information Encryption In article number 2206912, Wu, Zhang, Chen, and co-workers apply short alkyl chains modified polyvinyl alcohol as a molecular switch to control the static deformation of shape memory hydrogel. Thus, hydrogel morphologies can be encoded with encrypted morphological information, furtherly delivering hierarchical continuous information assistance programmed nea...

Statechart is a graphical technique for specification of reactive systems. Validation of a statechart model is very important due to its potential complexity and can be supported by different types of simulations: interactive, batch, programmed, exhaustive and prototyping. In this paper we present a language named Execution Control Language (ECL) to support the simulation of models based on ran...

Therapeutic strategies targeting the programmed cell death-ligand 1/programmed cell death-1 pathway have shown significant responses and good tolerability in solid malignancies. Although preclinical studies suggest that inhibiting programmed cell death-ligand 1/programmed cell death-1 interactions might also be highly effective in hematological malignancies, remarkably few clinical trials have ...

Some problems on guidance and robust gyromoment attitude control of agile spacecraft for remote sensing the Earth surface are considered. Elaborated methods for dynamic research of the spacecraft programmed angular motion at principle modes under external and parametric disturbances, partial discrete measurement of the state and digital control of the gyro moment cluster by the few-excessive gy...

Due to the increased popularity of e-learning, the phrase “blended learning” has recaptured people’s attention. The manner in which blended-learning classes can be designed to improve learning effectiveness has become an important issue. This study combines classroom learning (abbreviated as C) with computer-assisted programmed instruction (abbreviated as E) to implement C + E. Based on the pri...

This paper presents a study carried out to evaluate policy provisioning performance, by COPS-PR protocol, in a policy based environment. First of all the prototypes developed are presented. These simulate the component behavior of the two lower layers of a policy based management system. Then the various measurements, done on the prototypes, are shown. All measures are carried out for several s...