MOTIVATION The massive data produced by next-generation sequencing require advanced statistical tools. We address estimating the total diversity or species richness in a population. To date, only relatively simple methods have been implemented in available software. There is a need for software employing modern, computationally intensive statistical analyses including error, goodness-of-fit and...

IEEE Computer Graphics and Applications 11 The Optical Diagnostics and Applications Laboratory (ODALab) is investigating methods and technology for 3D visualization and imaging. Specifically, we’re integrating and assessing systems driven by real-world applications that can benefit from or enhance distributed collaborative environments. Although optics is at the core of the research program, th...

Hepatocellular carcinoma is one of the most serious complications of chronic liver disease and is the third most lethal cancer worldwide. Symptoms emerge very late in the course of its natural history with an attendant poor outcome. Screening is of paramount importance in a successful strategy to treat hepatocellular carcinoma. A successful screening program rests the availability of an at-risk...

The present paper addresses systematic approach to Condition-Based Maintenance, and research results at the University of South Carolina Condition-Based Maintenance Research Center, directly related to U.S. Army rotorcraft Vibration Management Enhancement Program. The paper gives an analysis of the CBM concept and its functional layers, such as condition monitoring, diagnostics, prognostics and...

The Optimization of Medical Accelerators (OMA) is the aim of a new European training network. OMA joins universities, research centers and clinical facilities with industry partners to address the challenges in treatment facility design and optimization, numerical simulations for advanced treatment schemes, and beam imaging and treatment monitoring. Projects include: compact accelerators for pr...

The University of Tennessee, Knoxville (UTK) and the Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, Brazil, have established a cooperative research program in the area of nuclear reactor monitoring and diagnosis. This effort explores the implementation of ongoing research and developing new automated monitoring and fault detection methods to improve the operational safety, re...

MOTIVATION The sensitivity and specificity of branched DNA (bDNA) assays are derived in part through the judicious design of the capture and label extender probes. To minimize non-specific hybridization (NSH) events, which elevate assay background, candidate probes must be computer screened for complementarity with generic sequences present in the assay. RESULTS We present a software applicat...

Companion diagnostics are integral to the application and success of personalized medicine. In oncology, many companion diagnostics are molecular-based, including a number of fluorescence in situ hybridization (FISH) based companion diagnostics. Here, we review the currently approved FISH based companion diagnostics and evaluate several new FISH assays as potential companion diagnostics.

The failure of medium voltage (MV) cables in North Queensland has led Ergon Energy to consider the relative economics of refurbishment or replacement. In order to provide data to inform decision making, an accelerated ageing program has been designed to investigate the ageing of new, field aged, and refurbished cables. This paper describes the considerations affecting the design of the ageing e...

Showcasing examples of the capabilities that National Nuclear Security Administration national laboratories and sites bring to the Stockpile Stewardship Program (SSP) is one of the key intents of the Stockpile Stewardship Quarterly (SSQ). SSQ articles celebrate representative successes of our programs that are made possible by the incredibly talented staff that contributes to these efforts. Thi...