Understanding the performance of business processes is an important part of any business process intelligence project. From historical information recorded in event logs, performance can be measured and visualized on a discovered process model. Thereby the accuracy of the measured performance, e.g., waiting time, greatly depends on (1) the availability of start and completion events for activit...

Introduction Dissolution is a characterization test commonly used by the pharmaceutical industry to guide formulation design and control product quality. Often, it is a required performance test for solid dosage forms,transdermal patches,and suspensions. It is also the only test that measures the rate of in vitro drug release as a function of time, which can reflect either reproducibility of th...

Current Computer Aided Design (CAD) software tools focus on rapid production of computer models, which usually takes place after the product design is completed. The product design process, which has more significant influence on product life-cycle costs, is not fully supported. This work documents the development of an automatic design and optimization system for industrial silencers. The deve...

This paper presents a methodology that incorporates simultaneous consideration of economic and environmental merit during the virtual prototyping phase of electronic product design. A model that allows optimization of a product life cycle, which includes primary assembly, disassembly, and secondary assembly using a mix of new and salvaged components, is described. Optimizing this particular lif...

Innovation is one of the main drivers of business success. Using computers and special software applications in support of innovations cannot only shorten the whole process of bringing an initial idea to life, but it can improve the overall decision making process. Moreover, aligning innovation management and product life cycle management (PLM) helps organizations in gaining and reusing importa...

The overall aim of the EU funded project ELIMA is to enable eco-efficient management and acquisition of product life cycle data by closing the information loop in different phases of product life cycle including design, manufacture, distribution, use, service-support, maintenance, and end-of-life product recovery. Information systems that can integrate information about products from all stages...

Process and product models are commonly used for performing life-cycle assessments (LCAs) of the environmental impacts of materials and products through different stages of fabrication, use, and end-of-life options. In this article, we show that these models can be represented as process flow diagrams or as matrices of process interactions. In either representation, the inventory of environment...

BACKGROUND Corn oil recovery and conversion to biodiesel has been widely adopted at corn ethanol plants recently. The US EPA has projected 2.6 billion liters of biodiesel will be produced from corn oil in 2022. Corn oil biodiesel may qualify for federal renewable identification number (RIN) credits under the Renewable Fuel Standard, as well as for low greenhouse gas (GHG) emission intensity cre...

During the regulatory requested process validation of pharmaceutical manufacturing processes, companies aim to identify, control, and continuously monitor process variation and its impact on critical quality attributes (CQAs) of the final product. It is difficult to directly connect the impact of single process parameters (PPs) to final product CQAs, especially in biopharmaceutical process deve...

When designing process-aware information systems, often variants of the same process have to be specified. Each variant then constitutes an adjustment of a particular process to specific requirements building the process context. Current Business Process Management (BPM) tools do not adequately support the management of process variants. Usually, the variants have to be kept in separate process...