نتایج جستجو برای: probucol

تعداد نتایج: 552  

2016
Huaying Fu Guangping Li Changle Liu Jian Li Lijun Cheng Wansong Yang Gary Tse Jichao Zhao Tong Liu

Diabetes mellitus (DM) increases the risk of developing atrial fibrillation (AF), but the molecular mechanisms of diabetes-induced atrial remodeling processes have not been fully characterized. The aim of this study was to examine the mechanisms underlying atrial ion channel remodeling in alloxan-induced diabetes model in rabbits. A total of 40 Japanese rabbits were randomly assigned to a contr...

Journal: :The Journal of biological chemistry 2001
W Takabe T Kodama T Hamakubo K Tanaka T Suzuki H Aburatani N Matsukawa N Noguchi

It has been proposed that phenolic antioxidants such as probucol exert their anti-atherogenic effects through scavenging lipid-derived radicals. In this study the potential for genomics to reveal unanticipated pharmacological properties of phenolic antioxidants is explored. It was found that two anti-atherogenic compounds, BO-653 and probucol, inhibited the expression of three alpha-type protea...

Journal: :The Journal of Japan Atherosclerosis Society 1983

2016
Sang - Man Jin Kyung Ah Han Jae Myung Yu Sung Hee Choi Choon Hee Chung Ie Byung Park Eun Jung Rhee Sei Hyun Baik Tae Sun Park You - Cheol Hwang

Journal: :American journal of physiology. Heart and circulatory physiology 2005
H Lou I Danelisen P K Singal

The current study investigated the phosphorylation of mitogen-activated protein kinases (MAPKs) as well as pro- and anti-apoptotic proteins in adriamycin (ADR)-induced cardiomyopathy (AIC) and heart failure in rats. Modulatory effects of antioxidant probucol on the activation of MAPKs were also examined. Male rats were administered with ADR (15 mg/kg body wt ip, over 2 wk) with and without prob...

Journal: :Circulation research 1998
D C Schwenke S R Behr

Several antioxidants inhibit atherosclerosis. This study investigated the hypothesis that combining vitamin E, a lipophilic antioxidant, with vitamin C, a hydrophilic antioxidant, and/or selenium, a cofactor of peroxidases that detoxify lipid peroxides, would inhibit atherosclerosis more effectively than vitamin E alone. We also considered whether regional variation in inhibition of atheroscler...

Journal: :Journal of lipid research 1992
L Schäfer Elinder G Walldius

A method is described for the simultaneous measurement of probucol, retinol, tocopherols, lycopene, and carotenes by reverse phase high performance liquid chromatography. A high sensitivity was achieved by use of a microbore column and by monitoring the effluent at the optimum wavelengths of each substance with a diode array detector. The detection limits were lycopene 0.5 ng; alpha-carotene, b...

Journal: :Circulation research 2010
Konstanze Beck Ben J Wu Jun Ni Fernando S Santiago Kristine P Malabanan Cheng Li Yutang Wang Levon M Khachigian Roland Stocker

RATIONALE induction of heme oxygenase (HO)-1 protects against experimental atherosclerotic diseases, and certain pharmacological HO-1 inducers, like probucol, inhibit the proliferation of vascular smooth muscle cells and, at the same time, promote the growth of endothelial cells in vivo and in vitro. OBJECTIVE because such cell-specific effects are reminiscent of the action of the transcripti...

Journal: :Circulation 2000
P W Serruys D P Foley B Höfling J Puel H D Glogar R Seabra-Gomes J Goicolea P Coste W Rutsch H Katus H Bonnier W Wijns A Betriu U Hauf-Zachariou E M van Swijndregt R Melkert R Simon

BACKGROUND In addition to its known properties as a competitive, nonselective beta and alpha-1 receptor blocker, carvedilol directly inhibits vascular myocyte migration and proliferation and exerts antioxidant effects that are considerably greater than those of vitamin E or probucol. This provides the basis for an evaluation of carvedilol for the prevention of coronary restenosis. METHODS AND...

Journal: :The Journal of clinical investigation 1995
N Santanam S Parthasarathy

Oxidation of LDL by peroxidases has been suggested to be a model for in vivo oxidation. The mechanism might involve the generation of an intermediate radical such as a phenoxy radical. We show that, in contrast to the oxidation of LDL by copper, oxidation by peroxidase system (H2O2/horse radish peroxidase) showed less resistance. This suggested that either the antioxidants were consumed more ra...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید