نتایج جستجو برای: proapoptotic gene

تعداد نتایج: 1144687  

2017
Fabio Arturo Grieco Guido Sebastiani Jonas Juan-Mateu Olatz Villate Laura Marroqui Laurence Ladrière Ksenya Tugay Romano Regazzi Marco Bugliani Piero Marchetti Francesco Dotta Décio L Eizirik

Type 1 diabetes (T1D) is an autoimmune disease leading to β-cell destruction. MicroRNAs (miRNAs) are small noncoding RNAs that control gene expression and organ formation. They participate in the pathogenesis of several autoimmune diseases, but the nature of miRNAs contributing to β-cell death in T1D and their target genes remain to be clarified. We performed an miRNA expression profile on huma...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2008
Zahidul Islam Colleen C Hegg Hee Kyong Bae James J Pestka

Satratoxin G (SG) is a macrocyclic trichothecene mycotoxin produced by Stachybotrys chartarum, a mold suggested to play an etiologic role in damp building-related illnesses. Acute intranasal exposure of mice to SG specifically induces apoptosis in olfactory sensory neurons of the nose. The PC-12 rat pheochromocytoma cell model was used to elucidate potential mechanisms of SG-induced neuronal ce...

Journal: :Cancer research 2008
Likun Li ElMoataz Abdel Fattah Guangwen Cao Chengzhen Ren Guang Yang Alexei A Goltsov A Craig Chinault Wei-Wen Cai Terry L Timme Timothy C Thompson

Glioma pathogenesis-related protein 1 (GLIPR1), a novel p53 target gene, is down-regulated by methylation in prostate cancer and has p53-dependent and -independent proapoptotic activities in tumor cells. These properties suggest an important tumor suppressor role for GLIPR1, yet direct genetic evidence of a tumor suppressor function for GLIPR1 is lacking and the molecular mechanism(s), through ...

Journal: :Molecular and cellular biology 2007
Nick Z Lu Jennifer B Collins Sherry F Grissom John A Cidlowski

Glucocorticoids are widely used in the treatment of inflammatory and other diseases. However, high-dose or chronic administration often triggers troublesome side effects such as metabolic syndrome and osteoporosis. We recently described that one glucocorticoid receptor gene produces eight translational glucocorticoid receptor isoforms that have distinct gene-regulatory abilities. We show here t...

Journal: :The Journal of pharmacology and experimental therapeutics 2005
Galen M Pieper Vani Nilakantan Min Chen Jing Zhou Ashwani K Khanna James D Henderson Christopher P Johnson Allan M Roza Csaba Szabó

Nitric oxide (NO) derived from inducible NO synthase has been implicated in cardiac rejection. However, little is known about the role of the reactive nitrogen species peroxynitrite. We examined the protective actions of a peroxynitrite decomposition catalyst, WW85, in an experimental model of acute cardiac rejection. Heterotopic, abdominal transplantation of rat donor hearts was performed. Gro...

Journal: :Science 2004
Jerry E Chipuk Tomomi Kuwana Lisa Bouchier-Hayes Nathalie M Droin Donald D Newmeyer Martin Schuler Douglas R Green

The tumor suppressor p53 exerts its anti-neoplastic activity primarily through the induction of apoptosis. We found that cytosolic localization of endogenous wild-type or trans-activation-deficient p53 was necessary and sufficient for apoptosis. p53 directly activated the proapoptotic Bcl-2 protein Bax in the absence of other proteins to permeabilize mitochondria and engage the apoptotic progra...

Journal: :Molecular and cellular biology 1999
G M Kasof L Goyal E White

The adenovirus E1B 19,000-molecular-weight (19K) protein is a potent inhibitor of apoptosis and cooperates with E1A to transform primary rodent cells. E1B 19K shows sequence and functional homology to the mammalian antiapoptotic gene product, Bcl-2. Like Bcl-2, the biochemical mechanism of E1B 19K function includes binding to and antagonization of cellular proapoptotic proteins such as Bax, Bak...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Hisashi Harada Bonnie Quearry Antonio Ruiz-Vela Stanley J Korsmeyer

The "BH3-only" proapoptotic BCL-2 family members initiate the intrinsic apoptotic pathway. A small interfering RNA knockdown of BIM confirms this BH3-only member is important for the cytokine-mediated homeostasis of hematopoietic cells. We show here that the phosphorylation status of BIM controls its proapoptotic activity. IL-3, a hematopoietic survival factor, induces extracellular signal-regu...

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