Abstract COVID-19 is a recent coronavirus outbreak caused by SARS-CoV-2 beginning in early December 2019 Wuhan China raising global health problems. The SARS main peptidase (SARS-CoV M(pro)) plays an essential role the life-cycle of virus and primary target for development anti-SARS agents. Also, viral 3-chymotrypsin-like cysteine protease 3 (3CLpro) enzyme controls replication its life cycle. ...

OBJECTIVE To recommend methods for assessing quality of care via patient-reported outcome-based performance measures (PRO-PMs) of symptoms, functional status, and quality of life. METHODS A Technical Expert Panel was assembled by the American Medical Association-convened Physician Consortium for Performance Improvement. An environmental scan and structured literature review were conducted to ...

Background: Different studies have investigated the association between p53 codon 72 Arg>Pro polymorphism and cancer risk. Because of the lack of consensus of the results in individual studies, we conducted this meta-analysis by pooling all currently available case–control studies to estimate the effect of p53 codon 72 Arg/Pro polymorphism on cancer susceptibility in Iranian population. ...

BACKGROUND Depressive mood and other emotional symptoms are common in multiple sclerosis (MS). The patient-reported outcome version of the "Echelle d'Humeur Dépressive" (EHD-PRO) aims to differentiate between two dimensions of depressive mood in people living with MS (PwMS). OBJECTIVES First, to compare EHD-PRO assessment and its two dimensions, lack of emotional control and emotional bluntin...

The 66-kDa leader proteinase (L-Pro) of the Beet yellows virus (BYV) possesses a nonconserved N-terminal domain and a conserved, papain-like C-terminal domain. Previous work revealed that the N-terminal domain functions in RNA amplification, whereas the C-terminal domain is required for autoproteolysis. Alanine-scanning mutagenesis was applied to complete the functional analysis of L-Pro throug...

My husband and I have been trying to conceive for two months now with no success. I'm 34 and he is 35. I have bought early ovulation tests and everything. My question to you is that it seems that my cervical fluid is never "egg white" slippery until a few days before my period. So what are some other symptoms that I need to pay attention to? I have been pregnant before but I terminated it. I wa...

My husband and I have been trying to conceive for two months now with no success. I'm 34 and he is 35. I have bought early ovulation tests and everything. My question to you is that it seems that my cervical fluid is never "egg white" slippery until a few days before my period. So what are some other symptoms that I need to pay attention to? I have been pregnant before but I terminated it. I wa...