background and objective: esophageal cancer especially squamous cell carcinoma (scc) is one of the most common gastro intestinal malignancies in north part of iran (khorasan). the standard treatment for esophageal cancer is surgical resection, but its outcome remains poor. then, the oncologists try to treat this cancer with sandwich protocols especially neo-adjuvant chemo-radiotherapy. several ...

background and objective: human papillomavirus (hpv) is one of the possible etiologic factors  in development of esophageal squamous cell carcinoma (escc). in this study we aimed to study the  role of hpv in escc. patients and methods:in this study, 140 cases of escc were analyzed for the hpv dna by  polymerase chain reaction (pcr) using gp5+/gp6+ primers for l1 open reading frame (orf) to  am...

background: esophageal squamous cell carcinoma (escc) is one of the lethal cancers with a high incidence rate in asia. many genes including cyclin d1 and p16 play important role in its carcinogenesis. we aimed to analyze the expressions of cyclin d1 and p16 with the various clinicopathological characteristics of escc.   method: we examined 30 biopsy samples of escc for cyclin d1 and p16 protein...

objective(s): variation in microsatellite sequences that are dispersed in the genome has been linked to a deficiency in cellular mismatch repair system and defects in several genes of this system are involved in carcinogenesis. our aim in this study was to illustrate microsatellite dna alteration in esophageal cancer. materials and methods: dna was extracted from formalin fixed paraffin embedde...

introduction: the human papilloma virus (hpv) can play a role in the development of head and neck squamous cell carcinoma (scc). our aim was to assess the prevalence of hpv dna in scc of the larynx. the impact of hpv infection on patient survival was also evaluated.  materials and methods: this case-control study was performed in 44 patients with scc of the larynx (case group), while the contro...

introduction: squamous cell carcinoma (scc) is the most common head and neck malignancy. smoking, alcohol consumption, viral infections, exposure, oral hygiene, and dietary, genetic, and occupational factors are the most important etiologic factors. the aim of this study was determining the incidence of etiologic factors in head and neck scc.  materials and methods: this is a cross-sectional su...

UNLABELLED We report the case of a 39-year-old female with primary vaginal squamous cell carcinoma arising from a squamous inclusion cyst of the posterior wall. The tumor was located in the vaginal wall and extended into the rectovaginal septum. The overlying mucosa was intact. Histologically, there was invagination of the surface squamous vaginal epithelium forming a cystic lesion. In some are...

OBJECTIVES/HYPOTHESIS Immunosuppression in organ transplant recipients increases the incidence and aggressiveness of cutaneous squamous cell carcinoma. However, there are little clinical data on cutaneous squamous cell carcinoma in patients with immunosuppression due to chronic lymphocytic leukemia. In this study we evaluated the clinical features, patterns of recurrence, and outcomes of cutane...

CS: carcinosarcoma IHC: immunohistochemistry PCCS: primary cutaneous carcinosarcoma SCC: squamous cell carcinoma SCM: spindle cell melanoma SMA: smooth muscle actin SpSCC: spindle cell squamous cell carcinoma INTRODUCTION Malignancy can develop after exposure to ionizing radiation. Basal cell carcinoma, squamous cell carcinoma (SCC), and sarcoma associated with ionizing radiation have been repo...

Sir, Primary squamous cell carcinoma of the rectum is a rare tumour. The diagnosis of squamous cell carcinoma rests on the exclusion of metastases from other organs, proximal extension of carcinoma arising from the anal canal and squamous-lined fistulous tracts. Here we report an uncommon presentation of rectal squamous cell carcinoma in a woman on long-term immunosuppressive therapy. 74 CORRES...