Glaucoma, a leading cause of blindness worldwide, is currently defi ned as a disturbance of the structural or functional integrity of the optic nerve that causes characteristic atrophic changes in the optic nerve, which may lead to specifi c visual fi eld defects over time. This disturbance usually can be arrested or diminished by adequate lowering of intraocular pressure (IOP). Glaucoma can be...

The epidemiology of eye Disease, 3rd edition, edited by Johnson GJ et al. The third edition of this authoritative text is 240 pages longer than the previous version and has 15 additional expert contributors. There is an extra chapter on research synthesis and an expanded section on visual impairment and blindness in children. Dry eye and uveitis now feature as separate entities, and the final t...

PURPOSE. To determine whether retinal vessel oxygen saturation is affected in primary open-angle glaucoma (POAG) patients. METHODS. Retinal oxygen saturation in patients with POAG was measured in retinal vessels with a spectrophotometric retinal oximeter in darkness, and visual fields were obtained. Oxygen tension (Po(2)) was calculated from oxygen saturation values. Statistical analysis was pe...

PURPOSE To analyze oxidative stress in primary open-angle glaucoma (POAG). MATERIAL AND METHODS A case-control study including 90 eyes of 90 patients who needed antiglaucomatous surgery in the course of POAG (glaucoma group, n=50) and from patients who were operated of nonpathologic cataracts (cataract group, n=40). Free radical formation via lipid peroxidation by malondialdehyde-thiobarbitur...

Primary open angle glaucoma (POAG) involves a spectrum of disorders typified by a characteristic optic neuropathy and field loss in eyes with open drainage angles. It is currently a leading cause of blindness worldwide, and in the future should become even more important as populations age throughout the world. Recently, we have witnessed a number of exciting advances in glaucoma. Developments ...

PURPOSE Primary open-angle glaucoma (POAG) is associated with a decreased content of hyaluronan in the trabecular meshwork and in the juxtacanalicular connective tissue. In this study, the authors examined selected regions of the anterior segment to localize and determine the content of CD44H, a transmembrane multifunctional glycoprotein and the principal receptor of hyaluronan. METHODS Secti...

Glaucoma is a complex genetic optic disease characterized by a range of optic neuropathies. There are many subtypes of glaucoma but primary open-angle glaucoma (POAG) associated with elevated intraocular pressure (IOP) is the most prevalent form. Based on the age of diagnosis, POAG is categorized as early-onset POAG or juvenile open-angle glaucoma (JOAG) diagnosed between 10 and 35 years and ad...

Purpose: The objective of this study was to identify possible risk factors associated with primary open-angle glaucoma (POAG). Methods: A case-control study included patients seen at Rasoul-Akram Hospital ophthalmology clinic. Cases were consecutive patients with confirmed unilateral or bilateral POAG presented during the study period. Controls were a random sample of all other patients aged 30...