Availability of an individualized preselection of oncolytic viruses to be used for virotherapy of tumor patients would be of great help. Using primary liver tumor resection specimens we evaluated the precision-cut liver slice (PCLS) technology as a novel in vitro test system for characterization of paramount tumor infection parameters of individual patients. PCLS slices from resection specimens...

Extranodal natural killer/T-cell (ENK/T) lymphoma is a rare neoplasm, subcategorized into ENK/T-nasal (ENK/T-N) and ENK/ T-nasal type (ENK/T-NT) lymphomas. ENK/ T-NT lymphoma with initial presentation in the skin is known as primary cutaneous ENK/T-NT (PC-ENK/T-NT) lymphoma. The aim of this study was to investigate pathogenesis, genomic alterations, and prognosis of cutaneous ENK/T lymphomas to...

The importance of alpha beta versus gamma delta T-cell subset antigen expression in the classification of peripheral T-cell lymphomas is still unclear. The objective of this study was to investigate the prognostic value of T-cell receptor-delta 1 (TCR delta 1) expression in primary cutaneous T-cell lymphomas. TCR delta 1 cellular expression was assessed in skin biopsy specimens of 104 individua...

Primary cutaneous lymphomas have been successfully treated with interferons (IFNs), counterbalancing the T-helper 2 (Th2)–skewing state. We undertook a phase 1, open-label, dose-escalating trial of repeated intratumoral administration of TG1042 in patients with advanced primary cutaneous T-cell lymphomas (CTCLs) and multilesional cutaneous B-cell lymphomas (CBCLs). TG1042 is a thirdgeneration, ...

Primary cutaneous lymphomas have been successfully treated with interferons (IFNs), counterbalancing the T-helper 2 (Th2)-skewing state. We undertook a phase 1, open-label, dose-escalating trial of repeated intratumoral administration of TG1042 in patients with advanced primary cutaneous T-cell lymphomas (CTCLs) and multilesional cutaneous B-cell lymphomas (CBCLs). TG1042 is a third-generation,...

I read with great interest the article by Magro and Wang1 on 5 cases of primary cutaneous gd T-cell lymphoma with an indolent course. These 5 patients had localized T-cell lymphoma in the subcutis with a less aggressive clinical course, and the authors raised the point that not all patients with primary cutaneous gd T-cell lymphoma have a poor prognosis. The major weakness of this article is th...

Overexpression of p53 protein in cutaneous T-cell lymphoma (CTCL) has been reported in primary cutaneous large T-cell lymphomas (PCLTCL) and has been associated with tumor progression and transformation in mycosis fungoides. However, the prognostic significance of p53 expression has not been studied thus far. In the present study we investigated the expression of p53 as well as bcl-2 protein in...

Mycosis Fungoides (MF) is the most common type of Cutaneous T-Cell Lymphoma (CTCL) and represents nearly 50% of all primary cutaneous lymphomas [1]. MF is characterized by an epidermotropic skin infiltrate of atypical CD4+ phenotype lymphocytes. In a minority of MF cases, the atypical infiltrate is CD8 positive. The later form of CTCL generally follows a rapid, aggressive clinical course [2]. H...

232 JEADV 2006, 20, 214–238 © 2005 European Academy of Dermatology and Venereology 3 Dargent JL, Sass U, Theunis A et al. Unusual T-cell pseudolymphoma with features of so-called pseudolymphomatous folliculitis. Dermatology 2002; 204: 159–161. 4 Baldassano MF, Bailey EM, Ferry JA et al. Cutaneous lymphoid hyperplasia and cutaneous marginal zone lymphoma: comparison of morphologic and immunophen...