نتایج جستجو برای: primary and metastatic melanoma

تعداد نتایج: 16947239  

2016
Anna A. Brożyna Wojciech Jóźwicki Krzysztof Roszkowski Jan Filipiak Andrzej T. Slominski

Melanin possess radioprotective and scavenging properties, and its presence can affect the behavior of melanoma cells, its surrounding environment and susceptibility to the therapy, as showed in vitro experiments. To determine whether melanin presence in melanoma affects the efficiency of radiotherapy (RTH) we evaluated the survival time after RTH treatment in metastatic melanoma patients (n = ...

Journal: :Molecular cancer research : MCR 2011
Yong Qin Suhendan Ekmekcioglu Ping Liu Lyn M Duncan Gregory Lizée Nancy Poindexter Elizabeth A Grimm

Interleukin (IL)-1-mediated inflammation is proposed to contribute to the development and progression of some cancers. IL-1 family member proteins are known to be expressed constitutively in many melanoma tumor cells, and we hypothesize that these support molecular pathways of inflammation and facilitate tumor growth. To investigate the expression of IL-1α and IL-1β in melanoma patients, and th...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Hanyang Lin Ronald P C Wong Magdalena Martinka Gang Li

PURPOSE Aberrant expression of SWI/SNF chromatin remodeling complex is involved in cancer development. The tumor suppressor SNF5, the core subunit of SWI/SNF complex, has been shown to regulate cell differentiation, cell cycle control, and apoptosis. To investigate the role of SNF5 in the development of melanoma, we examined the expression of SNF5 in melanocytic lesions at different stages and ...

2011
Yassir Sbitti Zouhour Fadoukhair Habiba Kadiri Mohamed Oukabli Ismail Essaidi Saoussan Kharmoum Hind M'rabti Abderrahmane Albouzidi Mohammed Ichou Hassan Errihani

BACKGROUND In the ovary, metastatic malignant melanoma may be confused with primary malignant melanoma and presents a diagnosis challenge. Most cases are associated with disseminated diseases and poor prognosis. We present this case report of a metastatic ovarian malignant melanoma simulating primary ovarian cancer. CASE REPORT A 45-year-old premenopausal woman was incidentally found to have ...

2013
Loretta Gammaitoni Lidia Giraudo Valeria Leuci Maja Todorovic Giulia Mesiano Franco Picciotto Alberto Pisacane Alessandro Zaccagna Maria Giuseppa Volpe Susanna Gallo Daniela Caravelli Elena Giacone Tiziana Venesio Antonella Balsamo Ymera Pignochino Giovanni Grignani Fabrizio Carnevale-Schianca Massimo Aglietta Dario Sangiolo

Purpose:We investigate the unknown tumor-killing activity of cytokine-induced killer (CIK) cells against autologous metastatic melanoma and the elusive subset of putative cancer stem cells (mCSC). Experimental Design:We developed a preclinical autologous model using same patient-generated CIK cells and tumor targets to consider the unique biology of each patient/tumor pairing. In primary tumor ...

Journal: :The Journal of investigative dermatology 2015
Linda Gao Karin van den Hurk Jérémie Nsengimana Jonathan P Laye Joost J van den Oord Samuel Beck Nelleke A Gruis Willem H Zoutman Manon van Engeland Julia A Newton-Bishop Véronique J Winnepenninckx Remco van Doorn

This is a PDF file of an unedited peer-reviewed manuscript that has been accepted for publication. NPG are providing this early version of the manuscript as a service to our customers. The manuscript will undergo copyediting, typesetting and a proof review before it is published in its final form. Please note that during the production process errors may be discovered which could affect the con...

Anshu Tewari GS Shagos, P Shanmuga Sundaram S Padma

Metastatic tumors to the heart unlike primary cardiac tumors are not rare. Despite its frequency, cardiac metastasis is commonly detected only during autopsy as the symptoms of disseminated metastasis prevail over symptoms caused by cardiac metastasis and hence is overlooked most of the time. Tumors more commonly found metastasizing to the heart are malignancies of lung, breast, esophagus, lymp...

2011
A Reid A Dettrick C Oakenful AL Lambrianides

Primary rectal melanoma is rare and only represents up to 4% of anorectal malignancies. The prognosis of such a diagnosis is significantly different to a metastatic melanoma deposit in the anorectal area and therefore differentiation between the two is of the utmost importance with regards to initial treatment and long-term management. Various immunohistochemical markers have been shown to be a...

Journal: :The British journal of ophthalmology 1993
J A Shields C L Shields R C Eagle P De Potter G L Oliver

A 76-year-old man with compressive optic neuropathy secondary to a retrobulbar mass was managed by orbitotomy and removal of the mass. The lesion proved histopathologically to be an unusual orbital melanoma with massive central necrosis. There was no histopathological evidence of congenital melanocytosis. Dermatological and systemic evaluation before and after orbital surgery revealed no eviden...

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