BACKGROUND The present study is designed to evaluate the reliability and cost effectiveness of cellulose acetate Hb electrophoresis and high performance liquid chromatography (HPLC) in the determination of HbA2 levels. METHODS The test population comprised 160 individuals divided into four groups: normal individuals, β-thalassemia trait (BTT) patients, iron deficiency anemia (IDA) patients, a...

Objectives: Accurately identifying the Antigens (Ags) on recipient red blood cells (RBCs) is critical in prevention of RBC alloimmunization in chronically transfused patients. The goal of this study was to compare RBC molecular genotyping to serological phenotyping in those patients. Methods: Serological phenotyping and molecular genotyping methods were used to study blood samples from 18 healt...

Background: Pain during invasive procedures is an unpleasant thing experienced by all children when hospitalized, including with acute illnesses or chronic diseases such as thalassemia. Nurses need to implement interventions from atraumatic care reduce the pain felt children, providing audiovisual distraction techniques. This study aimed see difference in thalassemia and non-thalassemia after b...

background: approximately 180 mutations have been described in β-thalassemia worldwide with specific spectrum in each ethnic population. this study determines the spectrum and the frequency of β-thalassemia mutations in patients with β-thalassemia trait and sickle cell-β-thalassemia.   methods: fifteen compound heterozygous sickle cell thalassemia (sct) and 23 β-thalassemia trait patients were ...

This is a report of couple with abnormal hematological indices who were investigated for α & β-thalassemia mutations. Based on CBC and capillary hemoglobin electrophoresis results, the male female subjects β α-thalassemia carriers, respectively. Multiplex-Gap-PCR Sanger sequencing techniques used identification mutations β-globin genes. The DNA test showed presence c.315 + 1 G > A mutati...

Eight thousand seven hundred and thirty-six pregnant women were screened for thalassemia and hemoglobinopathies by mean corpuscular volume less than 80 femtolitres (fl). Three thousand six hundred and seventy women (42%) were MCV less than 80 fl. In this group there were 2,390 women (70%) who had positive Hb typing by high performance liquid chromatography (HPLC) such as beta-thalassemia major,...

Thalassemia is a hematological disorder caused by gene mutation that leads to defective synthesis of hemoglobin complex. One the complications thalassemia hypocalcemia which presented with paresthesia, muscle spasm, low-serum calcium, and intracranial calcification. Hypocalcemia can affect thalassemic patients via various mechanisms. Blood transfusion-related transfusion-independent iron overlo...

Thalassemia is a hereditary disease caused by abnormalities in red blood cells which the individual has gene disorder that causes reduced production of hemoglobin cells. People with Thalassemia, especially type Major, need routine therapy and medication. These medication activities sometimes cause various problems obstacles lives people thalassemia both physically psychologically. Individuals a...

Thalassemia is a chronic disease that can affect quality of life. The purpose this study was to determine the effect family support, transfusion compliance and self-efficacy on life children with thalassemia. This research correlational cross-sectional approach. sample consisted 45 people. Data were collected using questionnaires, statistical analysis descriptive data respondents’ characteristi...