due to advanced treatments in the field of heart disease, cyanotic heart disease patients have a greater chance of survival, and nowadays many of them live until adolescence or middle age. one of the signs of this disease is blood hypoxia, which has acute and chronic effects on the cns. in this paper the effect of chronic hypoxia on children affected by cyanotic congenital heart disease (chd) i...

the influence of dissolved oxygen concentration on gill histopathology of great sturgeon (huso huso) was evaluated in two weight classes (initial weight 280.9?49.2 g and 1217.9?138.1 g respectively). oxygen treatments included hypoxia (2-3 mg/l), normoxia (5-6 mg/l) and hyperoxia (9-10 mg/l). the fish were acclimated to experimental tanks for one week then randomly distributed into 9 tanks in e...

a periodic increase in blood pressure (bp) occurs during apneic episodes in patients with obstructive sleep apnea (osa). several factors including hypoxemia and an increase in heart rate (hr) were reported to be responsible for this increased bp. to examine the contribution of these two factors in increasing bp, 35 healthy male subjects (mean age±sd= 23.64±3.80) were studied in three experiment...

background: mesenchymal stem cells (mscs) are important candidates for msc-based cellular therapy. current paradigm states that mscs support local progenitor cells in damaged tissue through paracrine signaling. therefore, study of paracrine effects and secretome of mscs could lead to the appreciation of mechanisms and molecules associated with the therapeutic effects of these cells. this study ...

  Objective(s): Hypoxia is a serious challenge for treatment of solid tumors. This condition has been manifested to exert significant therapeutic effects on glioblastoma multiform or (WHO) astrocytoma grade IV. Hypoxia contributes numerous changes in cellular mechanisms such as angiogenesis, metastasis and apoptosis evasion. Furthermore, in molecular level, hypoxia can cause induction of DNA br...

Effects of acute systemic hypoxia on the cardiovascular system (CYS) and respiration of spontaneously breathing cats were studied in two conditions. 1): Hypoxic air (6-8% 02 in N2) was given to the animal to induce systemic hypoxia for 20 minutes. Hyperventilation at this condition lowered arterial C02 tension (PaC02 hypocapnia). 2): In the second run, induction of hypocapnia was prevented ...

This review article provides information on the role of different methods for pregnant women to prepare childbirth according data regarding both foreign and domestic practices in obstetrics. The highlights issue partner support starting from when pregnancy is established gestation, through postpartum period. According research, it clear that physiological course directly depends psycho-emotiona...

background chronic hypoxia causes apoptosis of cardiac myocytes, however, energy production by anaerobic glycolysis protects myocardium against hypoxia injuries. aldolase a is a well-characterised key enzyme of the glycolysis pathway. ghrelin, a 28-amino-acid peptide, synthesizes in the stomach and has protective roles in cardiovascular systems and also affects metabolic pathways. objectives th...

Background: In recent decade, human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) provide enormous potential for appropriate cell therapy, but they have limited growth potential and cease to proliferate due to cellular senescence, so providing a strategy for increasing the stem cell survival is necessary.  Methods: In this investigation, MSCs characterized by flow cytome...