Anxiolytic drugs are widely used for premedication in oral surgery. Since anxiety is usually associated with the fear of pain, we tested the effects of the analgesic tramadol in premedication before operative extraction of the mandibular third molar under local anesthesia. In a double-blind crossover study, 20 patients were randomized to receive 100 mg oral tramadol or placebo 1 h before operat...

BACKGROUND Two previous phase II trials of docetaxels as first line chemotherapy of advanced breast cancer have been conducted by the Clinical Screening Group of the EORTC. In these 2 studies, docetaxel 100 mg/m2 and 75 mg/m2 were administered without routine premedication and produced overall response rates of 68% and 52% respectively. Fluid retention was the most problematic adverse event in ...

conclusions single dose of acetazolamide was associated with statistically significant decrease in shoulder pain immediately after laparoscopy. however, this effect was limited to the first postoperative hours and it failed to reduce postoperative pain of right shoulder during 24 hours after the operation. results administration of a single dose of acetazolamide did not have any statistically s...

background: paradoxical reactions to benzodiazepines including restlessness, anxiety and sometimes violent behavior sometimes occur. most of the known predicting factors of disinhibitory reactions such as age, gender, genetic or the psychological backgroundare not modifi able. th is study was conducted to evaluate the eff ect of rate of midazolam administration, as a controllable factor, on the...

background: although a variety of methods have been suggested to reduce stress, anxiety and pain intensity due to spinal needle skin puncture, their adverse effects restrict theirs widespread administration. in this study we evaluated the effects of oral tizanidine on the reduction of pain caused by spinal needle puncture and hemodynamic responses. methods : in this double blind randomized clin...

OBJECTIVE To investigate the incidence of difficulties associated with parental presence during the induction of anaesthesia in children and the influence of premedication with special reference to vomiting after papaveretum. DESIGN Mixed factual and multiple choice questionnaire completed by medical and nursing staff and parents during and after admission. SETTING Teaching hospital with re...

In 10 Nigerian patients undergoing upper abdominal surgery the plasma cortisol concentration was slightly decreased after premedication with pethidine and atropine, and during anaesthesia without surgery. There was a small increase during surgery. None of these changes was statistically significant. There was a significant increase in the postoperative period however. Premedication caused a sli...

Introduction and Objectives. Preanesthetic medication may reduce the risks of adverse psychological and physiological sequela of induction of anesthesia in children. Administration of premedication by sublingual route may provide the best compromise, that is, relatively rapid absorption without causing pain. In this study, we compared sedative and anxiolytic effects of midazolam and buprenorphi...