نتایج جستجو برای: preimplantation

تعداد نتایج: 5193  

Journal: :Human reproduction 1997
M Dan-Goor S Sasson A Davarashvili M Almagor

The expression of glucose transporters 1, 2, 3 and 4 was evaluated in human oocytes and polyploid preimplantation embryos. Only glucose transporter 1 (GLUT-1) isoform was detected in oocytes and in 2-12-cell stage embryos. Glucose uptake was markedly increased in embryos as compared to oocytes (19.7 +/- 3.4 pmol/min/embryo and 2.3 +/- 0.3 pmol/min/oocyte), and GLUT-1 was inhibited by cytochalas...

Journal: :Human reproduction 2008
Joe Leigh Simpson

The randomized clinical trial (RCT) is a powerful experimental design that when properly executed produces generalizable results. Conducting a RCT becomes complex when technical skills are required. Without requisite skills, a RCT may yield misleading results, an elegant RCT unwittingly generating spurious results due to technical inexperience. This pitfall is applicable to procedures used to e...

2013
Jennifer Saucier Katrina Merrion Janine Mash Barbara Pettersen Megan Hall Zachary Demko Santiago Munné

We read with interest the recent review by Santiago Munné entitled, “Preimplantation Genetic Diagnosis for Aneuploidy and Translocations Using Array Comparative Genomic Hybridization” (1). As part of the review of array comparative genome hybridization (aCGH), the author provides additional information on other 24-chromosome preimplantation genetic diagnosis/screening (PGD/PGS) techniques. As a...

Journal: :The Journal of Cell Biology 2000
Wolfgang Mayer Avril Smith Reinald Fundele Thomas Haaf

We have used two different experimental approaches to demonstrate topological separation of parental genomes in preimplantation mouse embryos: mouse eggs fertilized with 5-bromodeoxyuridine (BrdU)-labeled sperm followed by detection of BrdU in early diploid embryos, and differential heterochromatin staining in mouse interspecific hybrid embryos. Separation of chromatin according to parental ori...

Journal: :Molecular human reproduction 1998
C M Strom S Rechitsky G Wolf J Cieslak A Kuliev Y Verlinsky

A couple requested preimplantation genetic analysis for a dominant form of retinitis pigmentosum caused by a C-->A transversion in the rhodopsin gene. Since this point mutation does not alter a restriction endonuclease site we designed two separate analytical systems, one involving site-specific mutagenesis and the other involving allele-dependent length polymorphism. After establishing the acc...

2015
Mu Yuan Ming-Zhu Bai Xu-Feng Huang Yue Zhang Jing Liu Min-Hao Hu Wei-Qian Zheng Fan Jin

Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems. Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and widespread. They both have estrogenic properties and similar chemical structures and pharmacokinetic features and have been detected in human fluids and tissues. Clinical evidence has suggested a positive as...

Journal: :journal of reproduction and infertility 0

background: hla-g is a major histocompatibility complex (mhc), class ib molecule that is selectively expressed at the fetal–maternal interface. it is thought to play a role in protecting the fetus from the maternal immune response. interestingly, the preimplantation embryo development (ped) gene product qa-2 is also a mouse mhc class ib protein that affects cleavage and division of preimplantat...

Journal: :Reproductive BioMedicine Online 2007

Journal: :Fertility and sterility 2010
Jennifer L Eaton Michele R Hacker C Brent Barrett Kim L Thornton Alan S Penzias

A retrospective cohort study conducted in 138 patients undergoing their first preimplantation genetic screening (PGS) cycle between January 1, 2006, and December 31, 2007, demonstrated that embryos with good day-3 morphology were more likely to be euploid for X/Y, 8, 15, and 18 than those with poor morphology. The strength of association between euploidy and day-3 morphology was not influenced ...

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