Polymer nanoparticles are veritable tools for pharmacokinetic and therapeutic modifications of bioactive compounds. Nanoparticle technology development and scaling up are however often constrained due to poor payload and improper particle dissolution. This work was aimed to develop descriptor based computational models as prior art tools for optimal payload in polymeric nanoparticles. Loading o...

This study explores the mechanism(s) of airflow limitation following lung volume reduction surgery (LVRS) in patients with emphysema due to homozygous alpha1-antitrypsin (AT) deficiency. Bilateral targeted lower lobe stapled LVRS using video thoracoscopy was performed in six patients (five males) aged 61+/-9 yrs (mean+/-SD) with alpha1-AT emphysema. Two patients received only a 6-month follow-u...

OBJECTIVE To test whether adjuvant therapy with acetylsalicylic acid (ASA) and prednisolone (ASA+Pred) could improve the outcome of IVF in good-pregnancy prognosis patients. DESIGN Prospective, randomized study. SETTING University hospital. PATIENT(S) Three hundred ninety-five infertile couples undergoing IVF. INTERVENTION(S) Patients were randomized to receive ASA+Pred (n = 97) or noth...

Let A be a well-formed formula of first-order modal logic whose only free variable is x. We shall use the following abbreviations: Mat(A) for (x)[OA * 0~A] Form(A) for (x)[DA vD-i] Ban(A) for ((x)DA) v ((x)U~A) Pred(A) for Form(A) v Mat(A). We read Mat(A), FormjA), and Ban(A) respectively as: "A is material", "A is formal", and "A is banal"; Pred(A) is the assertion of the Principle of Predica-...

This work presents a simple artificial neural network which classifies proteins into two classes from their sequences alone: the membrane protein class and the non-membrane protein class. This may be important in the functional assignment and analysis of open reading frames (ORF's) identified in complete genomes and, especially, those ORF's that correspond to proteins with unknown function. The...

We investigate recognizing implied predicate-argument relationships which are not explicitly expressed in syntactic structure. While prior works addressed such relationships as an extension to semantic role labeling, our work investigates them in the context of textual inference scenarios. Such scenarios provide prior information, which substantially eases the task. We provide a large and freel...

Objectives: The aim of this ongoing randomized-controlled study is to examine the effects exercise training interventions with different intensities on peak capacity and body composition in adult people Cystic Fibrosis (pwCF). Methods: Up now 17 pwCF (10f/7 m) mean age 35 ± 5yrs (22–57yrs), ppFEV1 66.0 16.3%pred. (43.0–99.0%pred.) participated. Cycle-ergometry (Godfrey-protocol) was used determ...

S8 Figure 1. Ventilation images from (a) a healthy volunteer and (b-e) patients with mild CF. S9 SIFT-MS ANALYSIS AS A NON-INVASIVE DETERMINANT OF PSEUDOMONAS AERUGINOSA INFECTION IN PATIENTS WITH CYSTIC FIBROSIS R Pabary, S Kumar, J Huang, EWFW Alton, A Bush, GB Hanna, JC Davies; Royal Brompton and Harefield Hospital Foundation Trust, London, United Kingdom; Department of Cancer and Surgery, I...

Studi kasus dalam penelitian ini menggunakan subjek bernama KH dengan disabilitas intelektual ringan yang dilihat melalui kemampuan morfosintaksis subjek. Dalam metode asesmen untuk mengetahui morfologi dan sintaksis ketika berujar keseharian. Peneliti meminta menceritakan kegiatan sehari-hari diminta kembali dari gambar-gambar tersedia. Dari dapat dihasilkan bahwa membuat kalimat sudah mampu s...