This thesis describes the determination of a paired domainDNA complex crystal structure (involving the paired domain of the Drosophila Prd protein), and discusses the structural basis of DNA binding specificity of the paired domain and the structural basis of Pax developmental mutations. It also describes the cocrystallization of the human PAX6 paired domain-DNA complex. Chapter 1 provides an i...

Keyword: Pearl River Delta extreme water level sand excavation non-parameters test This paper is concerned with identifying the spatial and temporal patterns in the annual maximum and minimum water level in the Pearl River Delta (PRD) region. The Mann–Kendall test and Pettitt test are used to detect trends and abrupt change points, and the Trend Free Pre-Whitening (TFPW) approach then eliminate...

Dengue fever (DF) is one of the most common and rapidly spreading mosquito-borne viral diseases in tropical and subtropical regions. In recent years, this imported disease has posed a serious threat to public health in China, especially in the Pearl River Delta (PRD). Although the severity of DF outbreaks in the PRD is generally associated with known risk factors, fine scale assessments of area...

Surgery-induced acute postoperative pain and stress response may lead to prolonged convalescence. The present study was designed to investigate the effects of intraoperative dexmedetomidine on postoperative analgesia and recovery after abdominal colectomy surgeries.Sixty-seven patients scheduled for abdominal colectomy under general anesthesia were divided into two groups, which were maintained...

BACKGROUND Vascular calcifications have been documented in children with end-stage renal disease. However, only a few reports have described abundant dental calculus formation in children suffering from chronic kidney disease (CKD). Moreover, dental calculus scores (DCS) and their correlation with renal disease severity have not been studied. METHODS DCS in 74 young CKD patients were evaluate...

China has experienced unprecedented urbanization since the 1980s, resulting in substantial climatic effects from local cities to broad regions. Using the Weather Research and Forecasting model dynamically coupled to an urban canopy model, we quantified the summertime climate effects of urban expansion in China's most rapidly urbanizing regions: Beijing-Tianjin-Hebei (BTH), Yangtze River Delta (...

Pelvic radiation disease (PRD) occurs in 2-11% of patients undergoing pelvic radiation for urologic and gynecologic malignancies. Hyperbaric oxygen therapy (HBOT) has previously been described as a noninvasive therapeutic option for the treatment of PRD. the purpose of study was to analyze prospectively the results of HBOT in 44 consecutive patients with PRD who were resistant to conventional o...

Purpose. To evaluate whether prophylactic circumferential retinal cryopexy (CRC) can prevent pseudophakic retinal detachment (PRD) development after posterior capsule rupture (PCR) during phacoemulsification. Methods. Retrospective patient chart analysis of eyes experiencing a PCR during phacoemulsification. Comparison of PRD development between eyes receiving CRC (cryo+ group) or not (cryo- gr...

The Ou River, a medium-sized river in the southeastern China, is examined to study estuarine turbidity maximum (ETM) response rapidly varied discharge, i.e., peak discharge (PRD). This analyzes difference ETM and sediment transport mechanisms between low-discharge PRD during neap spring tides by using Finite-Volume Community Ocean Model. three-dimensional model validated in-situ measurements fr...