The ability of spiking neurons to synchronize their activity in a network depends on the response behavior of these neurons as quantified by the phase response curve (PRC) and on coupling properties. The PRC characterizes the effects of transient inputs on spike timing and can be measured experimentally. Here we use the adaptive exponential integrate-and-fire (aEIF) neuron model to determine ho...

The Polycomb repressive complexes (PRC) regulate self-renewal and differentiation in embryonic stem cells (ESCs). In this issue of Cell Stem Cell, Morey et al. (2012) and O'Loghlen et al. (2012) report that dynamic interchange of PRC subunits modulates the balance between self-renewal and lineage commitment in ESCs.

Y. LI*{, P. GONG{§ and T. SASAGAWA" {International Institute for Earth System Science, Nanjing University, Nanjing, Jiangsu, 210093, PRC {Institute of Remote Sensing Applications, Chinese Academy of Sciences, 100101, Beijing, PRC §Center for Assessment and Monitoring of Forest and Environmental Resources (CAMFER), UC Berkeley, 151 Hilgard Hall, Berkeley, CA, 94720-3110, USA "PASCO Corporation, ...

Adenosine acting through A(1) adenosine receptors (A1AR) has been shown previously to be required for the vasoconstriction elicited by high luminal NaCl concentrations at the macula densa (MD). The present experiments were performed to investigate a possible role of A1AR in MD control of renin secretion in conscious wild-type (WT) and A1AR-deficient mice. The intravenous injection of NaCl (5% b...

INTRODUCTION The clinical importance of postoperative episodic hypoxemia is still unclear, and therefore largely under-studied. As a result, there is limited understanding of its relationship with early postoperative respiratory complications (PRC, defined as intubation within three days of surgery) and hospital resource utilization. MATERIALS AND METHODS This single center study was performe...

In April 2004, the Canadian Association of Emergency Physicians (CAEP) Critical Care Committee committed to examine the evidence for therapeutic hypothermia after cardiac arrest and make recommendations on its use in the emergency department. The primary review committee (PRC) was made up of 5 members of the CAEP Critical Care Committee. All 5 members signed statements confirming that they had ...

Previous studies have shown that peripheral vestibular damage causes long-term neurochemical changes in the hippocampus which may be related to spatial memory deficits. Since recent studies have also demonstrated deficits in non-spatial object recognition memory following vestibular lesions, the aim of the present study was to extend these investigations into the perirhinal cortex (PRC), which ...

The renin-angiotensin-aldosterone system and cardiac natriuretic peptides [atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP)] are opposing control mechanisms for arterial blood pressure. Accordingly, an inverse relationship between plasma renin concentration (PRC) and ANP exists in most circumstances. However, PRC and ANP levels are both elevated in renovascular hypertension...

1. The renal artery to a lone remaining kidney was constricted in fourteen concious dogs. The following variables were measured in all animals: blood pressure (BP), cardiac rate (CR), plasma renin concentration (PRC), plasma volume (PV), extracellular fluid volume (ECFV) and plasma non-protein nitrogen (NPN). Sodium balance was estimated in eleven dogs. Cardiac output (CO), total peripheral res...

Generative approaches to pattern recognition and machine learning involve two aparts: first describing the underlying probability distributions and then using such models to compute probabilities or make classificatory decisions. We consider generative models for forensic evidence where the goal is to describe the distributions using graphical models and to use such models to compute probabilis...