Abstract Background The impact of malnutrition on outcomes in a contemporary ST-segment-elevation myocardial infarction (STEMI) population is unclear. We hypothesized that severity amongst STEMI patients undergoing primary percutaneous coronary intervention (pPCI) associated with worse long-term outcomes. Purpose aim this study was 2-fold: 1) to establish the prevalence among pPCI; 2) determine...

Abstract Background Primary percutaneous coronary intervention (PPCI) is the standard reperfusion treatment in ST-segment elevation myocardial infarction (STEMI). However, PPCI often complicated by microvascular obstruction. Intracoronary thrombolysis (ICT) may mitigate thrombotic burden. Methods We conducted, according to PRISMA statement, largest meta-analysis of ICT as adjuvant therapy PPCI....

several studies have reported that the antioxidant properties of melatonin can provide cardiac protection through scavenging of free radicals. this study sought to investigate the efficacy of melatonin on cardiac biomarkers, myocardial-specific protein high sensitive troponin-t (hs-tnt) and creatine kinase-mb (ck-mb), in patients with st-segment elevation myocardial infarction (stemi) undergoin...

Introduction According to the World Health Organization, in the period 2004–2030 year cardio-vascular diseases will remain a leading cause of human deaths on global scale. Among these, the major cause of mortality are the acute coronary syndromes (ACS). Key aspects of controlling the ACS are the early diagnostics and the early reperfusion therapy—primary percutaneou coronary intervention (PPCI)...

Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is timely and effective myocardial reperfusion using either thombolytic therapy or primary percutaneous coronary intervention (PPCI). However, the process of reperfusion can itself induce cardiomyocyt...

The authors investigated trends in the Croatian primary Percutaneous Coronary Intervention (pPCI) Network results among three consecutive time intervals (2005-2007, first phase; 2008-2009, second phase; and 2010-2011, third phase). Data on 5650 patients with acute myocardial infarction with ST-elevation (STEMI) transferred or directly admitted and treated with pPCI in 11 Croatian PCI centers du...

OBJECTIVE Clinical studies using serum cardiac biomarkers to investigate a circadian variation in acute myocardial infarct (MI) size in ST-segment elevation myocardial infarction (STEMI) patients reperfused by primary percutaneous coronary intervention (PPCI) have produced mixed results. We aimed to investigate this phenomenon using acute MI size measured by cardiovascular magnetic resonance (C...

BACKGROUND we have found that remote ischemic conditioning (rIC), adjunctive to primary angioplasty, increases myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) and extensive myocardial area at risk (AAR). The present substudy aimed to evaluate the short-term effects of rIC on left ventricular (LV) function. METHODS AND RESULTS patients with a first STEMI ...

BACKGROUND AND OBJECTIVE The aim of this study was to evaluate and compare various parameters between complete and incomplete ST-segment resolution (STR) patients' groups and to identify associates of STR in patients with acute ST-segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (PPCI) (primary outcome). MATERIALS AND METHODS A total of 203 cons...

BACKGROUND To understand the influence of age on treatment and outcomes, we analyzed the largest group of patients 75 years or older with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention (PPCI) in a clinical trial. METHODS We analyzed data from 5745 patients in the Assessment of Pexelizumab in Acute Myocardial Infarction trial from July 13, 20...