OBJECTIVES Electrical inhomogeneity between ischemic and non ischemic myocardium is the basis of arrhythmia which occurs following coronary artery occlusion. The leakage of potassium from the ischemic region to the non ischemic region is very effective in the generation of these arrhythmias. The aim of this study is to research the effect of ATP-dependent potassium (KATP) channel blocker (glibe...

Eleven commercially available alcohol and ethylene glycol derivatives were tested for their toxicity toward a problem organism in jet fuel, Cladosporium resinae. In the presence of glucose, 20% (vol/vol) ethylene glycol monomethyl ether prevented spore germination and mycelial growth, and 10% (vol/vol) 2-ethoxybutanol, 10% 2-isopropoxyethanol, 10% 3-methoxybutanol, 5% 2-butyloxyethanol, 5% ethy...

The photodynamic action of riboflavin is generally considered to involve the generation of reactive oxygen species, whose production is enhanced when Cu(II) is present in the reaction. In the present study we report that photoactivated riboflavin causes K(+) loss from fresh human red blood cells (RBC) in a time dependent manner. Addition of Cu(II) further enhances the K(+) loss and also leads t...

Cerebral focal ischemia is a local degeneration of brain tissue induced by a reduction of blood supply. We introduce a mathematical model that includes the blood dynamics, represented by a flow in a porous medium and ion dynamics (calcium and potassium), together with other variables (energy stores, tissue integrity, oxygen and glucose) representing the biochemical events consequent to the vess...

The economic and environmental losses due to serious leakage in the urban water supply network have increased the effort to control the water leakage. However, current methods for leakage estimation are inaccurate leading to the development of ineffective leakage controls. Therefore, this study proposes a method based on the blind source separation theory (BSS) to calculate the leakage of water...

one of the important factors influencing outdoor insulators performance is pollution phenomenon. the pollution, especially during humidity condition, reduces superficial resistance of insulator and lead to a flow of leakage currents (lc) on the insulator surface, which may result in total flashover. the lc characteristics are affected by parameters such as nature and severity of pollution. loca...

The permeability of K channels to various cations is studied in myelinated nerve. Ionic currents under voltage clamp are measured in Ringer solution containing tetrodotoxin and a high concentration of the test ion. Reversal potentials for current in K channels are determined and used with the Goldman-Hodgkin-Katz equation to calculate relative permeabilities. The ratios PTI:PK:PRb:PNH4 are 2.3:...

TTX and TEA-insensitive permeabilities were studied in the crab giant axon under voltage-clamp. Membrane currents in the presence of internal TEA (40 mmol/l) and external TTX (300 nmol/l) may be analyzed as the sum of two components: a linear component, identified as the so-called leakage current, and a non-linear component, identified as a TEA-insensitive potassium channel. Ion permeability ra...

Based on the structure-activity relationship data of BMY-28864 and related pradimicin derivatives, the calcium salt-forming ability and the D-mannopyranoside-specific visible absorption maximum shift of BMY-28864 were analysed in the ternary complex formation of BMY-28864 with D-mannopyranoside and calcium. The free C-18 carboxyl group of BMY-28864 was proved to be the sole site for binding to ...

Chlorella autotrophica (Clone 580) grows over the external salinity range of 1 to 400% artificial sea water (ASW), can photosynthesize over the range from 1 to 600% ASW, and survives the complete evaporation of seawater. The alga grown at high salinities shows an increase in cell volume and a small decrease in cell water content. Measurements of ion content were made by neutron activation analy...