A facile procedure is described for the preparation of [ "C]epicholesterol from [ '*C]cholesteroL Cholesterol is first converted to cholesteryl mesylate, which is treated with cesium acetate and 18-crown-6 in refluxing toluene to give epicholesteryl acetate. The latter is hydrolyzed, without isolation, with potassium hydroxide in tetrahydrofuran-methanol to give epicholesterol, which is obtaine...

Diethyl 2-nitro-(pentafluorosulfanyl)benzylphosphonates, available by the vicarious nucleophilic substitution reaction of meta- and para-nitro-(pentafluorosulfanyl)benzenes and diethyl chloromethylphosphonate, undergo Horner-Wadsworth-Emmons reaction with aldehydes in the presence of potassium hydroxide in acetonitrile at ambient temperature to give (E)-2-nitro-1-alkenyl-(pentafluorosulfanyl)be...

An efficient method for the direct N-alkylation of indoles via copper-catalyzed reductive cross coupling between N-tosylhydrazones and indole reagents has been developed. The reaction was performed in the presence of copper iodide and potassium hydroxide by utilization of tri(p-tolyl)phosphine as a ligand. A wide variety of N-alkylated indoles were obtained in moderate to good yields. The appli...

Abbreviations: AIDS, acquired immune deficiency syndrome; ARDS, adult respiratory distress syndrome; BAL, bronchoalveolar lavage; CSF, cerebrospinal fluid; CMV, cytomegalovirus; CNS, central nervous system; CT, computed tomography; DNA, deoxyribonucleic acid; EIA, enzyme immunoassay; GMS, Grocott methenamine-silver; HIV, human immunodeficiency virus; HPLC, high performance liquid chromatography...

The work described herein employs potassium hydroxide impregnated alumina (KOH-alumina) as a mild, efficient, and recyclable catalyst for a one-pot solvent-free and environmentally safer synthesis of 3,4,6-triarylpyridazines and some substituted pyridazines from active methylene carbonyl species, 1,2-dicarbonyls, and hydrazine hydrate by microwave (MW) irradiation. The method offers highly conv...

The simultaneous occurrence of brain stem glioma and disseminated Strongyloides stercoralis infestation in an Ecuadorian male is reported. The unusual finding of Strongyloides larvae in the potassium hydroxide preparation for fungi and in the Gram stain for bacteria from a sputum during hemoptysis fortuitously established the diagnosis of disseminated strongyloidiasis. Of interest was the demon...

A convenient one-pot reaction was conducted by mixing bromoacetophenone, a functionalized α,β-unsaturated ketone and potassium hydroxide in tetrahydrofuran at room temperature, ammonium acetate was added and heated to reflux, resulting in four chemical bonds forming from easily accessible substrates. This process provides a flexible and rapid synthetic route for the construction of polysubstitu...

In this study, biodiesel production from microalgal oil by microwave-assisted transesterification was carried out to investigate its efficiency. Transesterification reactions were performed by using Chlorella protothecoides oil as feedstock, methanol, and potassium hydroxide as the catalyst. Methanol:oil ratio, reaction time and catalyst:oil ratio were investigated as process parameters affecte...

We have modified the procedure of Levy [Ann. C/in. Lab. Sd. 6, 474 (1972)] for determination of serum triglycerides. The changes consist of using heptane in place of normane; using concentrated aqueous potassium hydroxide instead of sodium methylate as the saponifying reagent; and a somewhat higher saponification, oxidation, and condensation temperature. Consequently, the yellow dehydrolutidine...

A catalytic asymmetric conjugate arylation of acyclic alpha,beta-unsaturated ketones with arylboronic acids was catalyzed by 3 mol% of chiral amidomonophosphane 1-rhodium(I) in the presence of potassium hydroxide in a mixture of 1,4-dioxane and water at 70 degrees C to afford 1,4-conjugate arylated acyclic ketones with high enantiomeric excess in high chemical yield. Thirteen examples of the re...