The review is devoted to the genetic nature of congenital glaucoma (CG) and presents clinical forms hereditary single nucleotide polymorphisms identified by genome-wide association studies (GWAS). Glaucoma a genetically heterogeneous disease, patients with same diagnosis often have different molecular causes. role mutations in CYP1B1 gene has been proven pathogenesis hydrophthalmos; MYOC — juve...

We present cases of primary open angle glaucoma patients without previous history of pseudoexfoliation who developed pseudoexfoliative materials on the anterior surface of the intraocular lens after cataract surgery. Among 5 unilateral pseudophakic pseudoexfoliation cases, 3 showed a more advanced state of glaucoma in the affected eye. The other 2 cases showed progression of glaucoma in the aff...

Objective To investigate the causes of secondary glaucoma in retinoblastoma (RB) and underscore the significance of glaucoma as a presenting sign of RB. Methods A 7-month-old boy, initially diagnosed with congenital glaucoma in the left eye (OS), revealed an intraocular RB on further work-up. The eye was eventually enucleated and histopathology showed iris neovascularization (NVI) and a large s...

Glaucoma is the main cause of irreversible blindness worldwide. In short, it a multifactorial progressive optic neuropathy that correlates with retinal ganglion cell death, nerve head disturbances, and visual field disorders. Leuprolide acetate have recently been reported to neurotrophic properties, aim this work was determine whether it´s systemic administration holds up neurodegenerative proc...

purpose : there are controversial reports regarding the long-term intraocular pressure (iop) lowering effect of non-penetrating glaucoma surgery (npgs). the reported complete success rates from studies in different populations around the world are 13% to 77%. this prospective study was aimed to evaluate the iop lowering effect of deep sclerectomy with mitomycin c (dsmmc) in a group of iranian p...

AIM The objective of our work was to determine whether there is a difference in fMRI activation between patients with high tension glaucoma (HTG) and those with normal tension glaucoma (NTG). METHOD The sample consisted of eight patients with different stages of high tension glaucoma (3 females aged 41-65 and 5 males aged 40-73 years) and eight patients, also with different stages of normal t...

PURPOSE To report the results of screening first degree relatives of persons identified with primary open angle glaucoma in a tertiary eye hospital glaucoma services. DESIGN A cross-sectional study of first degree relatives of persons with primary open angle glaucoma. MATERIALS AND METHODS First degree relatives of patients identified with primary open angle glaucoma were invited to partici...

OBJECTIVES To report the incidence of glaucoma and glaucoma suspects in the IATS, and to evaluate risk factors for the development of a glaucoma-related adverse event in patients in the IATS in the first year of follow-up. METHODS A total of 114 infants between 1 and 6 months of age with a unilateral congenital cataract were assigned to undergo cataract surgery either with or without an intra...

OBJECTIVE The aim of this study was to evaluate patients' dissatisfaction with overall and specific aspects of a tertiary glaucoma service and to determine their independent factors, including intraocular pressure (IOP) and visual acuity (VA). METHODS Patients, aged ≥21 years, from a specialist glaucoma service in a tertiary eye hospital in Singapore for at least 6 months, were recruited for ...

PURPOSE Glutathione S-transferases (GSTs) are a family of enzymes that inactivate xenobiotics and endogenous end products formed as secondary metabolites during oxidative stress. In humans, GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0, and T0M0) are associated with a variety of pathologic processes including certain ophthalmologic diseases. METHODS We compared the prevalence of GSTT1 and GS...